Potency of naloxone's anorectic effect in rats is dependent on diet preference
Potency of naloxone's anorectic effect in rats is dependent on diet preference
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DOI：
10.1152/ajpregu.1996.271.1.r217
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发表时间：
1996-07-01
影响因子：
2.8
通讯作者：
Levine, AS
中科院分区：
文献类型：
--
作者：
Glass, MJ;Grace, M;Levine, AS
神经肽Y （NPY）和阿片样物质对摄食行为的调节已经得到了很好的证实，但这些神经影响可能会引发特定的食欲，如NPY对碳水化合物的食欲和阿片样物质对脂肪的食欲。在其他研究中，NPY刺激后的标准食物摄入可以被纳洛酮阻断，这表明这些系统在喂养调节中存在相互作用。本实验考察了npy -阿片相互作用在饮食选择中的本质。大鼠同时给予NPY和纳洛酮，然后在高脂肪和高碳水化合物饮食中进行选择。皮下给药纳洛酮（0.01-0.3 mg/kg）能有效减少首选饮食的摄入量，但对非首选饮食没有作用。在另一项单独的实验中也发现了类似的选择模式，在24小时的食物剥夺后，给予相同剂量的纳洛酮。这些数据支持了阿片系统调节进食的“奖励”方面的观点。
Modulation of feeding behavior by neuropeptide Y (NPY) and opioids is well established, but the possibility that these neural influences provoke specific appetites, NPY for carbohydrate and opioids for fat, has also been considered. In other studies, intake of standard chow after NPY stimulation can be blocked by naloxone, indicating an interaction between these systems in the regulation of feeding. The present experiments examined the nature of NPY-opioid interactions in diet selection. Rats were administered NPY and naloxone concurrently, then chose between high-fat and high-carbohydrate diets. Subcutaneous administration of naloxone (0.01-0.3 mg/kg) potently reduced intake of the preferred diet, but not the nonpreferred diet. A similar pattern of selection was seen in a separate experiment where the same doses of naloxone were administered after 24-h food deprivation. These data support the idea that the opioid system mediates the ''rewarding'' aspects of feeding.