Complementary Strategies for Directed C(sp(3) )-H Functionalization: A Comparison of Transition-Metal-Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer.
Complementary Strategies for Directed C(sp(3) )-H Functionalization: A Comparison of Transition-Metal-Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer.
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DOI：
10.1002/anie.201703743
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发表时间：
2018-01-02
期刊：
影响因子：
--
通讯作者：
Rovis T
中科院分区：
文献类型：
--
作者：
Chu JCK;Rovis T
sp3 C-H键官能化通过允许使用简单分子并提供新的合成断开来简化化学合成。由于近年来人们致力于开发基于C-H官能化方法的新反应，其在分子衍生化和复杂分子合成中的益处已被认识到。本文讨论了未活化的sp3 C-H键的直接功能化的三种主要方法，即过渡金属催化的C-H键活化、1，n氢原子转移和过渡金属催化的碳烯/氮烯转移的优缺点。对于每一种策略，范围，不同的C-H键的反应性，反应的C-H键相对于导向基团的位置，和立体化学的结果与文献中的例子说明。本文旨在为C-H官能化反应的使用者提供指导，并对该领域的未来研究有所启发。
sp3 C-H bond functionalization streamlines chemical synthesis by allowing the use of simple molecules and providing novel synthetic disconnection. Due to recent intense efforts devoted to develop new reactions based on the approach of C-H functionalization, its benefits in molecule derivatization and complex molecule synthesis have been recognized. This article discusses the strength and weakness of three main approaches, transition-metal catalyzed C-H activation, 1, n hydrogen atom transfer and transition-metal catalyzed carbene/nitrene transfer, for directed functionalization of unactivated sp3 C-H bonds. For each strategy, the scope, the reactivity of different C-H bonds, the position of the reacting C-H bonds relative to the directing group, and stereochemical outcomes are illustrated with examples in literature. The aim of this review is to provide guidance for users of C-H functionalization reactions and inspire future research in this area.
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影响因子：
2.3
作者：
BALAVOINE, G;CLINET, JC
通讯作者：
CLINET, JC
影响因子：
15
作者：
CANE, DE;THOMAS, PJ
通讯作者：
THOMAS, PJ
影响因子：
15
作者：
Aihara, Yoshinori;Chatani, Naoto
通讯作者：
Chatani, Naoto
影响因子：
3.6
作者：
Bogen, S;Gulea, M;Malacria, M
通讯作者：
Malacria, M
DOI：
10.1039/p19870000937
发表时间：
1987-04-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
影响因子：
--
作者：
CARRAU, R;HERNANDEZ, R;BETANCOR, C
通讯作者：
BETANCOR, C