Toxic neuropathy in patients with pre-existing neuropathy
Toxic neuropathy in patients with pre-existing neuropathy
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DOI：
10.1212/01.wnl.0000043691.53710.53
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发表时间：
2003-01-28
期刊：
影响因子：
9.9
通讯作者：
Griffin, JW
中科院分区：
文献类型：
--
作者：
Chaudhry, V;Chaudhry, M;Griffin, JW
作者报告了6名接受“无毒”剂量已知神经毒性药物的患者的既存神经病变显著恶化。治疗前，基线总神经病变评分（TNS）平均为9.5（范围0 - 19）。化疗（泰素[125 - 175 mg/m2 × 4];长春新碱[2 - 5 mg];顺铂[40 mg/m2 × 8];沙利度胺[60 g]）后，TNS平均为22（范围13 - 29）。作者得出结论，在标准剂量下，既存神经病变患者可能发生功能性致残性毒性神经病变。
The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol [125 to 175 mg/m(2) X 4]; vincristine [2 to 5 mg]; cisplatin [40 mg/m(2) x 8]; and thalidomide [60 g]), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.