Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay
Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay
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DOI：
10.1126/science.aat2952
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发表时间：
2018-11-09
期刊：
影响因子：
56.9
通讯作者：
Zugaro, Michael
中科院分区：
文献类型：
--
作者：
Drieu, Celine;Todorova, Ralitsa;Zugaro, Michael
空间和情景记忆的巩固被认为依赖于睡眠期间神经元活动序列的重放。然而，在清醒状态下最初存储记忆的网络动力学从未被测试过。虽然缓慢的行为时间尺度序列被认为可以维持连续记忆的形成，但嵌套在缓慢序列中的快速（“theta”）时间尺度序列可能是有用的。我们发现，在模型火车上被动旅行的大鼠中，位置细胞形成了行为时间尺度序列，但θ序列被降解，导致随后的睡眠重放受损。相比之下，当老鼠在火车上行驶时在跑步机上积极跑步时，位置细胞在睡眠期间产生清晰的θ序列和准确的轨迹回放。我们的研究结果支持这样一种观点，即嵌套序列是记忆痕迹最初形成的基础，随后在睡眠中巩固。
Consolidation of spatial and episodic memories is thought to rely on replay of neuronal activity sequences during sleep. However, the network dynamics underlying the initial storage of memories during wakefulness have never been tested. Although slow, behavioral time scale sequences have been claimed to sustain sequential memory formation, fast ("theta") time scale sequences, nested within slow sequences, could be instrumental. We found that in rats traveling passively on a model train, place cells formed behavioral time scale sequences but theta sequences were degraded, resulting in impaired subsequent sleep replay. In contrast, when the rats actively ran on a treadmill while being transported on the train, place cells generated clear theta sequences and accurate trajectory replay during sleep. Our results support the view that nested sequences underlie the initial formation of memory traces subsequently consolidated during sleep.