miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11.
miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11.
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miR-23b 通过直接靶向 IL-11 抑制 SMMC-7721 细胞增殖
DOI：
10.3892/mmr.2018.9151
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发表时间：
2018-08
影响因子：
3.4
通讯作者：
Zeng Q
中科院分区：
文献类型：
--
作者：
Jiang T;Huang Z;Zhang S;Zou W;Xiang L;Wu X;Shen Y;Liu W;Zeng Z;Zhao A;Zhou S;Zeng Q
肝细胞癌（HCC）是21世纪癌症相关死亡的第三大原因。microRNA (miR)-23b已被证明参与许多癌症的发病机制，包括乳腺癌和前列腺癌。然而，miR-23b在HCC中的作用尚不清楚。本研究揭示了miR-23b在HCC组织中的表达与癌的进展呈负相关。与正常组织相比，HCC组织中miR-23b表达显著下调，而白细胞介素(IL)-11和IL-11受体α (IL- 11r α)表达显著上调，表明miR-23b表达与IL-11和IL- 11r α表达呈负相关。此外，miR-23b抑制SMMC-7721细胞增殖，促进细胞凋亡。这种作用是由IL-11介导的，本研究发现IL-11是miR-23b的直接靶点。这些结果表明，miR-23b可调控IL-11和IL-11Rα的表达，并可能通过直接下调IL-11的表达，在HCC的发展过程中发挥抑癌作用。
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality in the 21st century. microRNA (miR)-23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR-23b in HCC remains unclear. The present study revealed a negative correlation between miR-23b expression in HCC tissues and progression of carcinomas. Compared to normal tissues, miR-23b expression was significantly downregulated in HCC tissues, whereas the expression of interleukin (IL)-11 and IL-11 receptor α (IL-11Rα) was significantly upregulated, indicating that miR-23b expression is negatively correlated with IL-11 and IL-11Rα expression. In addition, miR-23b inhibited proliferation and promoted apoptosis of SMMC-7721 cells. This effect was mediated by IL-11, which was found to be the direct target of miR-23b in this study. These results indicated that miR-23b regulates IL-11 and IL-11Rα expression, and might act as an anti-oncogenic agent in the progression of HCC by directly downregulating IL-11 expression.
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影响因子：
--
作者：
Grossi I;Arici B;Portolani N;De Petro G;Salvi A
通讯作者：
Salvi A
影响因子：
4
作者：
Furugaki, Koh;Moriya, Yoichiro;Iwai, Toshiki;Yorozu, Keigo;Yanagisawa, Mieko;Kondoh, Kumiko;Fujimoto-Ohuchi, Kaori;Mori, Kazushige
通讯作者：
Mori, Kazushige
影响因子：
--
作者：
Liu, Hui;Li, Wenzheng;Long, Xueying
通讯作者：
Long, Xueying
影响因子：
11.2
作者：
Lewis, Valerae O.;Ozawa, Michael G.;Pasqualini, Renata
通讯作者：
Pasqualini, Renata
影响因子：
30.8
作者：
Chang, Tsung-Cheng;Yu, Duonan;Mendell, Joshua T.
通讯作者：
Mendell, Joshua T.