Improved in vivo stability of silicon-containing polyurethane by fluorocarbon side chain modulation of the surface structure.
Improved in vivo stability of silicon-containing polyurethane by fluorocarbon side chain modulation of the surface structure.
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DOI：
10.1039/d1tb00140j
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发表时间：
2021-04
期刊：
影响因子：
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通讯作者：
Lin Tang;Xirui Long;Xueling He;Mingming Ding;Daiguo Zhao;F. Luo;Jiehua Li;Zhen Li;Hong Tan;Hengyu Zhang
中科院分区：
文献类型：
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作者：
Lin Tang;Xirui Long;Xueling He;Mingming Ding;Daiguo Zhao;F. Luo;Jiehua Li;Zhen Li;Hong Tan;Hengyu Zhang
作为一类广泛使用的生物医学材料，聚氨酯在体内的稳定性不足。尽管商业化的硅树脂-聚醚醚酮（SiPEU）与聚醚醚酮（PEU）相比具有良好的生物稳定性，可用于长期植入，但聚二甲基硅氧烷（PDMS）的使用不可避免地降低了机械性能，并观察到意外的破坏。在本研究中，我们将氟化二醇（FDO）引入到SiPEU中，以调节分子间的相互作用和微观分离的形态。氟化含硅聚氨酯（FSiPEU）实现了理想的硅和氟富集的表面和机械性能在低硅含量。如通过巨噬细胞的体外培养和体内苏木精-伊红（H&E）染色所证明的，FSiPEU表现出最小化的炎症反应。植入小鼠体内6个月后，材料没有明显的表面降解，软段的链断裂最少。结果表明，考虑到生物稳定性、生物相容性和机械性能的组合，FSiPEU可能是有希望的长期植入候选物。
As a class of widely used biomedical materials, polyurethanes suffer from their insufficient stability in vivo. Although the commercialized silicone-polyetherurethanes (SiPEUs) have demonstrated excellent biostability compared with polyetherurethanes (PEUs) for long-term implantation, the usage of polydimethylsiloxane (PDMS) inevitably decreased the mechanical properties and unexpected breaches were observed. In this study, we introduced a fluorinated diol (FDO) into SiPEU to modulate the molecular interactions and micro-separated morphology. The fluorinated silicon-containing polyurethane (FSiPEU) was achieved with desirable silicone- and fluorine-enriched surfaces and mechanical properties at a low silicon content. As evidenced by in vitro culture of macrophages and in vivo hematoxylin-eosin (H&E) staining, FSiPEU demonstrated a minimized inflammatory response. After implantation in mice for 6 months, the material was devoid of significant surface degradation and had the least chain cleavage of soft segments. The results indicate that FSiPEU could be promising candidates for long-term implantation considering the combination of biostability, biocompatibility and mechanical performances.