Striatopallidal Pathway Distinctly Modulates Goal-Directed Valuation and Acquisition of Instrumental Behavior via Striatopallidal Output Projections
Striatopallidal Pathway Distinctly Modulates Goal-Directed Valuation and Acquisition of Instrumental Behavior via Striatopallidal Output Projections
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纹状体苍白球通路通过纹状体苍白球输出预测明显调节目标导向的评估和工具行为的获取。
DOI：
10.1093/cercor/bhz172
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发表时间：
2020-03-01
期刊：
影响因子：
3.7
通讯作者：
Chen, Jiang-Fan
中科院分区：
文献类型：
--
作者：
He, Yan;Li, Yan;Chen, Jiang-Fan
纹状体通路专门用于控制运动和动机行为，但其在纹状体控制工具学习中的因果作用尚不明确（部分原因是混淆运动效应）。在这里，我们利用瞬态和“时间锁定”的光遗传学操作与奖励传递来最小化运动混淆效应，以更好地定义纹状体对仪器行为的控制。光遗传（Arch）沉默背内侧纹状体（DMS）和背外侧纹状体（DLS）的纹状体通路分别促进了目标导向行为和习惯行为，但不影响工具行为的习得，说明生理条件下纹状体通路抑制了工具行为。相反，纹状条通路的激活主要通过光遗传（ChR2）或化学遗传（hM3q）激活、强（10mW而非弱1mW）光遗传激活、带奖励的时间锁定（而非随机）光遗传激活和DMS（而非DLS）纹状条通路实现的获取抑制来影响工具行为的获得。最后，纹状伞通路通过纹状伞输出投射到外苍白球（GPe）来调节工具行为，因为DMS中的纹状伞通路和GPe中的纹状伞输出投射的光遗传激活类似地抑制目标导向行为。因此，纹状体通路通过输出投射到GPe，在正常和过度激活条件下，对动物对目标导向评估和工具行为获取的敏感性进行了独特的抑制控制。
The striatopallidal pathway is specialized for control of motor and motivational behaviors, but its causal role in striatal control of instrumental learning remains undefined (partly due to the confounding motor effects). Here, we leveraged the transient and "time-locked" optogenetic manipulations with the reward delivery to minimize motor confounding effect, to better define the striatopallidal control of instrumental behaviors. Optogenetic (Arch) silencing of the striatopallidal pathway in the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) promoted goal-directed and habitual behaviors, respectively, without affecting acquisition of instrumental behaviors, indicating striatopallidal pathway suppression of instrumental behaviors under physiological condition. Conversely, striatopallidal pathway activation mainly affected the acquisition of instrumental behaviors with the acquisition suppression achieved by either optogenetic (ChR2) or chemicogenetic (hM3q) activation, by strong (10mW, but not weak 1mW) optogenetic activation, by the time-locked (but not random) optogenetic activation with the reward and by the DMS (but not DLS) striatopallidal pathway. Lastly, striatopallidal pathway modulated instrumental behaviors through striatopallidal output projections into the external globus pallidus (GPe) since optogenetic activation of the striatopallidal pathway in the DMS and of the striatopallidal output projections in the GPe similarly suppressed goal-directed behavior. Thus, the striatopallidal pathway confers distinctive and inhibitory controls of animal's sensitivity to goal-directed valuation and acquisition of instrumental behaviors under normal and over-activation conditions, through the output projections into GPe.