Immunohistochemical study on 70 human embryos concerning the epidermal binding of pemphigus and pemphigoid antibodies.
Immunohistochemical study on 70 human embryos concerning the epidermal binding of pemphigus and pemphigoid antibodies.
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对 70 个人类胚胎进行的有关天疱疮和类天疱疮抗体表皮结合的免疫组织化学研究。
DOI：
10.2340/0001555560129133
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发表时间：
1980
影响因子：
3.6
通讯作者：
J. Stratigos
中科院分区：
文献类型：
--
作者：
A. Varelzidis;A. Tosca;E. Coumantakis;G. Nicolis;J. Hatzis;S. Papavasiliou;J. Stratigos
本研究采用间接免疫荧光技术，分别利用天疱疮患者血清和大疱性类天疱疮患者血清，在人胎皮肤抗原底物上研究了天疱疮和大疱性类天疱疮抗原的发展。对妊娠9-38周的70例胚胎皮肤标本进行了研究。天疱疮和大疱性类天疱疮抗原在妊娠约16周时首次被观察到。天疱疮抗原的进化速度较慢。在30至38周之间，检测到这两种抗原均为强阳性。
In the present study, the development of pemphigus and bullous pemphigoid antigens was investigated by means of the indirect immunofluorescence technique using sera of pemphigus and bullous pemphigoid patients, respectively, on human foetus skin antigenic substrate. Seventy skin specimens from embryos of 9-38 weeks of gestation were studied. Both pemphigus and bullous pemphigoid antigens were observed for the first time at about 16 weeks of gestation. Pemphigus antigen has a slower rate of evolution. Between 30 and 38 weeks both antigens were detected as strongly positive.