Modulating the immune system through nanotechnology.

Modulating the immune system through nanotechnology.
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通过纳米技术调节免疫系统。

DOI:
10.1016/j.smim.2017.09.007
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发表时间:
2017-12
影响因子:
7.8
通讯作者:
Alonso MJ
Alonso MJ
中科院分区:
医学2区
文献类型:
--
作者:
Dacoba TG;Olivera A;Torres D;Crecente-Campo J;Alonso MJ

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如今,基于纳米技术的免疫系统调节作为一种前沿策略被提出,这可能会导致严重疾病治疗的显着改善。特别是,努力的重点是开发基于纳米技术的疫苗,这种疫苗可用于免疫或产生耐受性。在这篇综述中,我们强调了如何通过调整纳米系统的性质来引发不同的免疫反应。此外,我们还讨论了为开发抗感染和抗自身免疫疫苗而设计的具体配方方法,以及那些旨在防止形成针对生物制剂的抗体的方法。
Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals.
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