Histofluorescence techniques provide evidence for dopamine-containing neuronal elements in canine kidney.
Histofluorescence techniques provide evidence for dopamine-containing neuronal elements in canine kidney.
复制标题
组织荧光技术为犬肾中含有多巴胺的神经元元素提供了证据。
DOI：
10.1126/science.451614
复制
发表时间：
1979
期刊：
影响因子：
56.9
通讯作者：
P. Hoffmann
中科院分区：
文献类型：
--
作者：
R. Dinerstein;J. Vannice;Richard Henderson;Lloyd J. Roth;Leon I. Goldberg;P. Hoffmann
盐酸引起犬肾血管支配相关的儿茶酚胺荧光团激发谱的变化表明，肾小球血管极含有以多巴胺为主的神经元成分。相反，弓状动脉外膜层中的儿茶酚胺荧光来自去甲肾上腺素。含有多巴胺的结构可能代表肾血管中药物识别的多巴胺受体的结合前对应物。因此，该系统可能参与肾血流和肾素释放的正常调节。
Changes induced by hydrochloric acid in the excitation spectrum of catecholamine fluorophores associated with the innervation of the canine renal vasculature show that there are neuronal elements at the glomerular vascular poles containing predominantly dopamine. In contrast, the catecholamine fluorescence in the periadventitial layer of the arcuate arteries is derived from norepinephrine. The dopamine-containing structures may represent the prejunctional counterpart to the pharmacologically identified dopamine receptors in the renal vasculature. As such, this system may be involved in the normal regulation of renal blood flow and renin release.