Improving the photothermal therapy efficacy and preventing the surface oxidation of bismuth nanoparticles through the formation of a bismuth@bismuth selenide heterostructure
Improving the photothermal therapy efficacy and preventing the surface oxidation of bismuth nanoparticles through the formation of a bismuth@bismuth selenide heterostructure
复制标题
通过形成铋@硒化铋异质结构提高光热治疗效果并防止铋纳米粒子的表面氧化
DOI：
10.1039/d0tb00825g
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发表时间：
2020
影响因子：
7
通讯作者：
Xi Li
中科院分区：
文献类型：
--
作者：
Bing Li;Yan Cheng;Runxiao Zheng;Xiaqing Wu;Fan Qi;Yunyun Wu;Yaqing Hu;Xi Li
铋纳米粒子(NPs)是一种很有前途的光热剂，可用于计算机断层成像引导的光热治疗。然而，提高它们的光热转化效率和防止它们的氧化是具有挑战性的。由于Bi2Se3和Bi2Se3之间的能级错开，本文设计并制备了具有核壳结构的Bi2Se3纳米粒子，以提高其光热性能。在近红外光照射下，这两种材料都具有极窄的带隙，可以被激发产生热载流子。热电子转移到Bi2Se3的导带，热空穴转移到Bi2Se3的价带，导致热载流子的有效分离。然后，这些热电子和空穴将在Bi2Se3和Bi2Se3的界面上以非辐射的方式复合，产生更多的声子，导致增强的光热转换效率。此外，由于Bi2Se3具有较高的稳定性，Bi2Se3在BiNPs表面的存在可以防止Bi2Se3的表面氧化。事实上，Bi@Bi2Se3纳米粒子对癌细胞具有良好的生物相容性和光热治疗效果。
Bismuth (Bi) nanoparticles (NPs) are emerging as promising photothermal agents for computed tomography imaging-guided photothermal therapy. However, it is challenging to improve their photothermal conversion efficacy and prevent their oxidation. Herein, Bi@bismuth selenide (Bi2Se3) core@shell NPs were designed and fabricated for improving the photothermal performance due to the staggered energy levels between Bi and Bi2Se3. With near-infrared light irradiation, both the materials could be excited to generate hot carriers due to their extremely narrow bandgaps. The hot electrons would transfer to the conduction band of Bi2Se3 and the hot holes to the valence band of Bi, leading to the effective separation of hot carriers. Then, these hot electrons and holes would recombine nonradiatively at the interface of Bi and Bi2Se3 and produce more phonons, resulting in an enhanced photothermal conversion efficacy. Moreover, the presence of Bi2Se3 on the surface of Bi NPs could prevent Bi from surface oxidation due to the higher stability of Bi2Se3. In fact, Bi@Bi2Se3 NPs showed excellent biocompatibility and photothermal therapeutic efficacy against cancer cells.