Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval
Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval
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DOI：
10.1038/jes.2010.3
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发表时间：
2011-05-01
影响因子：
4.5
通讯作者：
Mccaffrey, Robert J.
中科院分区：
文献类型：
--
作者：
Seegal, Richard F.;Fitzgerald, Edward F.;Mccaffrey, Robert J.
迄今为止，对多氯联苯在人体内半衰期的大多数估计都是基于相对较短的随访期。为了解决这一问题，我们确定了职业来源的PCB同系物的半衰期在前电容器工人的血清中作为2003-2006年进行的研究的一部分-大约28年后，他们最后一次职业接触。共241人从6798前电容器工人的源人口进行了采访，并要求捐献血液样本的血清PCB同系物分析。一个由45名参与者组成的亚组也有1976年存档的血清，并由同一实验室重新分析了相同的27种PCB同系物。我们对这45人体内同系物半衰期的估计比Wolff等人（1992年）报告的估计要长，主要是因为接触和测定血清多氯联苯浓度之间的间隔时间要长得多。重职业同系物的半衰期明显大于轻职业同系物，女性明显大于男性，初始接触量低的人明显大于初始接触量高的人。目前，以湿重数据的几何平均数表示的整个241人队列的血清总多氯联苯浓度平均为6.7纳克/克，这比1970年代末报告的值下降了10倍，但仍接近居住在同一地区但没有职业接触的类似年龄的人的平均值的两倍。此外，目前的血清PCB浓度仍然显着和积极相关的早期职业暴露，但没有与淡水鱼消费。总的来说，结果支持一个一致的和长期的趋势，增加PCB的身体负担，在这个队列的前电容器工人相比，非职业暴露的个人。这些结果可能有助于进一步了解人类接触多氯联苯的毒理学/流行病学后果。Journal of Exposure Science and Environmental Epidemiology（2011）21，234-246; doi：10.1038/jes.2010.3; 2010年3月10日在线发表
To date, most estimates of the half-life of polychlorinated biphenyls (PCBs) in humans have been based on relatively short follow-up periods. To address this issue, we determined the half-lives of PCB congeners of occupational origin in the serum of former capacitor workers as part of a study conducted in 2003-2006 - approximately 28 years after their last occupational exposure. A total of 241 persons from a source population of 6798 former capacitor workers were interviewed and asked to donate a blood sample for serum PCB congener analysis. A subgroup of 45 participants also had serum archived from 1976 and reanalyzed for the same 27 PCB congeners by the same laboratory. Our estimates of the half-lives of the congeners among these 45 persons were longer than those reported by Wolff et al. (1992), due primarily to the much longer interval between exposure and determination of serum PCB concentrations. Half-lives were significantly greater for the heavy versus light occupational congeners, for women versus men and for those with low versus high initial exposure. Current serum total PCB concentrations, expressed as the geometric mean of wet weight data, averaged 6.7 ng/g for the entire 241-person cohort, which represents a 10-fold decrease from values reported in the late 1970s, but is still nearly twice the average for persons of similar age residing in the same area, but without occupational exposure. In addition, current serum PCB concentrations remained significantly and positively associated with earlier occupational exposure, but were not associated with fresh water fish consumption. In general, the results support a consistent and long-duration trend of increased PCB body burden in this cohort of former capacitor workers compared with non-occupationally exposed individuals. The results may aid in further understanding the toxicological/epidemiological consequences of exposure to PCBs in humans. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 234-246; doi:10.1038/jes.2010.3; published online 10 March 2010