Sedentary Behavior and Health: Update from the 2018 Physical Activity Guidelines Advisory Committee
Sedentary Behavior and Health: Update from the 2018 Physical Activity Guidelines Advisory Committee
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DOI：
10.1249/mss.0000000000001935
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发表时间：
2019-06-01
期刊：
影响因子：
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通讯作者：
Whitt-Glover, Melicia C.
中科院分区：
文献类型：
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作者：
Katzmarzyk, Peter T.;Powell, Kenneth E.;Whitt-Glover, Melicia C.
目的：概述2018年身体活动指南咨询委员会科学报告（2018 PAGAC科学报告）中报告的久坐行为与死亡率以及几种非传染性疾病发病率和体重状况之间的关系，并更新近期研究的证据。方法：总结2018年PAGAC科学报告中与久坐行为相关的证据，并对2017年1月至2018年2月发表的原始研究进行系统评价。结果：2018年PAGAC科学报告得出结论，有强有力的证据表明，长时间久坐会增加全因心血管疾病（CVD）死亡率、CVD发病率和2型糖尿病的风险。中度证据表明久坐行为与子宫内膜癌、结肠癌和肺癌的发生有关。有限的证据表明，久坐行为与癌症死亡率和体重状况有关。有强有力的证据表明，久坐行为的有害影响在不运动的人身上更为明显。证据不足以确定久坐行为的时间长短或间断是否与健康结果相关。新的文献检索产生了七项关于全因死亡率的新研究，两项关于心血管疾病死亡率的研究，两项关于癌症死亡率的研究，四项关于2型糖尿病的研究，一项关于体重状况的研究，四项关于癌症的研究；没有新的研究发现心血管疾病的发病率。新研究的结果支持了2018年PAGAC科学报告中的结论。结论：最新的研究结果进一步证明了久坐行为与健康之间的联系。性别、年龄、种族/民族、社会经济地位和体重状况如何影响久坐行为与健康结果之间的关系，还需要进一步的研究。
Purpose: To provide an overview of relationships between sedentary behavior and mortality as well as incidence of several noncommunicable diseases and weight status reported in the 2018 Physical Activity Guidelines Advisory Committee Scientific Report (2018 PAGAC Scientific Report), and to update the evidence from recent studies. Methods: Evidence related to sedentary behavior in the 2018 PAGAC Scientific Report was summarized, and a systematic review was undertaken to identify original studies published between January 2017 and February 2018. Results: The 2018 PAGAC Scientific Report concluded there was strong evidence that high amounts of sedentary behavior increase the risk for all-cause and cardiovascular disease (CVD) mortality and incident CVD and type 2 diabetes. Moderate evidence indicated sedentary behavior is associated with incident endometrial, colon and lung cancer. Limited evidence suggested sedentary behavior is associated with cancer mortality and weight status. There was strong evidence that the hazardous effects of sedentary behavior are more pronounced in physically inactive people. Evidence was insufficient to determine if bout length or breaks in sedentary behavior are associated with health outcomes. The new literature search yielded seven new studies for all-cause mortality, two for CVD mortality, two for cancer mortality, four for type 2 diabetes, one for weight status, and four for cancer; no new studies were identified for CVD incidence. Results of the new studies supported the conclusions in the 2018 PAGAC Scientific Report. Conclusions: The results of the updated search add further evidence on the association between sedentary behavior and health. Further research is required on how sex, age, race/ethnicity, socioeconomic status, and weight status may modify associations between sedentary behavior and health outcomes.