Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis
Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis
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DOI：
10.1016/s0022-5347(01)66201-3
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发表时间：
1996-05-01
影响因子：
6.6
通讯作者：
Woodworth, BE
中科院分区：
文献类型：
--
作者：
Buffington, CAT;Blaisdell, JL;Woodworth, BE
目的：比较正常猫与患间质性膀胱炎（IC）的猫的尿蛋白和糖胺聚糖（GAG）的排泄情况。据报道，IC可减少人类尿GAG的排泄。材料和方法：全尿GAG；用1,9-二甲基亚甲基蓝（DMB）氯分光光度法测定随机尿样和24小时尿样的浓度。结果：在随机尿样和24小时尿样中，IC猫的GAG和蛋白质浓度以及GAG：肌酐和蛋白质：肌酐比值均显著降低，IC猫24小时尿样中总GAG和蛋白质排泄量也显著降低。结论：IC猫的GAG排泄量与人类一样减少。目前尚不清楚这是由于合成、代谢或膀胱渗透性的改变。
Purpose: The urine protein and glycosaminoglycan (GAG) excretion of normal cats was compared with that of cats suffering from interstitial cystitis (IC), which is reported to decrease urine GAG excretion in humans.Materials and Methods: Total urine GAG; concentration was measured in random and 24-hour urine specimens by spectrophotometry by 1,9-dimethylmethylene blue (DMB) chloride.Results: In both random and 24-hour urine samples, GAG and protein concentrations and GAG:creatinine and protein:creatinine ratios all were significantly lower in cats with IC. Total GAG and protein excretion also were significantly lower in 24-hour urine samples from cats with IC.Conclusions: GAG excretion was decreased in cats with IC, as it is in humans. It is unclear whether this is due to changes in synthesis, metabolism, or bladder permeability.