Regulation of hepatic blood flow: The hepatic arterial buffer response revisited
Regulation of hepatic blood flow: The hepatic arterial buffer response revisited
复制标题
DOI：
10.3748/wjg.v16.i48.6046
复制
发表时间：
2010-12-28
影响因子：
4.3
通讯作者：
Vollmar, Brigitte
中科院分区：
文献类型：
--
作者：
Eipel, Christian;Abshagen, Kerstin;Vollmar, Brigitte
对肝脏的兴趣可以追溯到古代，当时它被认为是生命过程的所在地。肝脏确实是生命所必需的，这不仅是因为它在生物合成、代谢和清除方面的复杂功能，而且还因为它作为血容量储存器的戏剧性作用。在实质器官中，由于来自门静脉和肝动脉的双重供应，流向肝脏的血液是独特的。了解肝动脉和门静脉的相互交通是了解肝脏生理和病理生理的基础。要区分这些流入在正常和异常状态下的个人重要性仍然是一个具有挑战性的任务和正在进行的研究的主题。控制和允许肝血流恒定的中心机制是肝动脉缓冲反应。本文综述了这种密切的肝血流调节系统在健康和疾病的相关性。我们专注于肝切除和移植中肝动脉和门静脉流入回路之间的内源性相互关系，以及炎症和慢性肝病。我们不考虑肝脏微血管解剖，因为这是最近另一篇综述的主题。(C)2010年百世登。All rights reserved.
The interest in the liver dates back to ancient times when it was considered to be the seat of life processes. The liver is indeed essential to life, not only due to its complex functions in biosynthesis, metabolism and clearance, but also its dramatic role as the blood volume reservoir. Among parenchymal organs, blood flow to the liver is unique due to the dual supply from the portal vein and the hepatic artery. Knowledge of the mutual communication of both the hepatic artery and the portal vein is essential to understand hepatic physiology and pathophysiology. To distinguish the individual importance of each of these inflows in normal and abnormal states is still a challenging task and the subject of ongoing research. A central mechanism that controls and allows constancy of hepatic blood flow is the hepatic arterial buffer response. The current paper reviews the relevance of this intimate hepatic blood flow regulatory system in health and disease. We exclusively focus on the endogenous interrelationship between the hepatic arterial and portal venous inflow circuits in liver resection and transplantation, as well as inflammatory and chronic liver diseases. We do not consider the hepatic microvascular anatomy, as this has been the subject of another recent review. (C) 2010 Baishideng. All rights reserved.