Impact of Immune-Modulatory Drugs on Regulatory T Cell.
Impact of Immune-Modulatory Drugs on Regulatory T Cell.
复制标题
DOI：
10.1097/tp.0000000000001379
复制
发表时间：
2016-11
期刊：
影响因子：
6.2
通讯作者：
Tang Q
中科院分区：
文献类型：
--
作者：
Furukawa A;Wisel SA;Tang Q
选择性抑制效应T细胞，同时保留甚至增强CD4+FOXP3+调节性T细胞（Treg）的免疫抑制策略允许免疫自我调节，并可使免疫抑制和相关毒性最小化。在认识到Treg的特性和功能之前，开发了许多免疫抑制药物。了解Treg与免疫抑制剂之间的相互作用对于设计更耐受的免疫抑制方案具有重要意义。本综述将讨论临床前和临床证据的影响，目前和新兴的免疫抑制药物对Treg的稳态，稳定性和功能的Treg友好的免疫抑制方案的选择和发展的指导方针。
Immunosuppression strategies that selectively inhibit effector T cells while preserving and even enhancing CD4+FOXP3+ regulatory T cells (Treg) permit immune self-regulation and may allow minimization of immunosuppression and associated toxicities. Many immunosuppressive drugs were developed before the identity and function of Treg were appreciated. A good understanding of the interactions between Treg and immunosuppressive agents will be valuable to the effective design of more tolerable immunosuppression regimens. This review will discuss preclinical and clinical evidence regarding the influence of current and emerging immunosuppressive drugs on Treg homeostasis, stability, and function as a guideline for the selection and development of Treg-friendly immunosuppressive regimens.