Transgenic mouse models of venous thrombosis: Fulfilling the expectations?
Transgenic mouse models of venous thrombosis: Fulfilling the expectations?
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DOI：
10.1055/s-2007-985758
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发表时间：
2007-09-01
影响因子：
5.7
通讯作者：
Reitsma, Pieter H.
中科院分区：
文献类型：
--
作者：
Cleuren, Audrey C. A.;van Viijmen, Bart J. M.;Reitsma, Pieter H.
在过去的15年中，已经产生了转基因小鼠，其携带天然抗凝剂途径的缺陷和/或突变等位基因，并显示自发血栓形成表型。随着这些小鼠品系的产生，更好的机会可用于研究静脉血栓形成的现有和新的风险因素。此外，这些模型可以作为评估新的抗血栓策略的工具。本文综述了这些小鼠模型，并评估它们是否达到了预期目标。
During the last 15 years, transgenic mice have been generated that carry defective and/or mutant alleles of the natural anticoagulant pathways and display a spontaneous thrombotic phenotype. With the generation of these mouse lines, better opportunities became available for investigating both existing and novel risk factors for venous thrombosis. In addition, these models could serve as a tool for evaluating novel antithrombotic strategies. This review summarizes these mouse models and evaluates whether they have fulfilled the expectations.