REGULARITY OF COCHLEAR NUCLEUS STELLATE CELLS - A COMPUTATIONAL MODELING STUDY
REGULARITY OF COCHLEAR NUCLEUS STELLATE CELLS - A COMPUTATIONAL MODELING STUDY
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DOI：
10.1121/1.405694
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发表时间：
1993-06-01
影响因子：
2.4
通讯作者：
MEDDIS, R
中科院分区：
文献类型：
--
作者：
HEWITT, MJ;MEDDIS, R
本文报道了一个旨在研究耳蜗核星状细胞瞬态斩波响应的计算机模拟研究。该模型是基于一个模拟的听觉周边饲料一个通用的星状细胞模型。瞬态斩波器单位的生理记录响应于短，最佳频率，纯音显示了一个短暂的初始期（通常< 10 ms）的快速频率适应证明了迅速上升的平均峰间期。与这种频率适应相关的是放电不规则性的显著增加。速率和不规则性的变化最近被归因于细胞上噪声抑制输入的激活[例如，Banks和Sachs，《神经生理学杂志》。65，606-629（1991）]。然而，结果表明，瞬态斩波器响应模式可以产生，而不需要抑制输入。初始斩波模式的瞬态对以下模型参数敏感：（a）细胞的放电阈值，（B）聚集在细胞上的兴奋性输入的数量，以及（c）针对每个有效输入传递到细胞的电流的幅度。该反应也被发现是相对不敏感的树突过滤的程度上施加的神经输入的变化。每个模拟的结果可以通过考虑在音调突发的过程中细胞接收的去极化模式来解释。
This article reports on a computational modeling study designed to investigate the generation of the transient chopper response of cochlear nucleus stellate cells. The model is based on a simulation of the auditory periphery which feeds a generic stellate-cell model. Physiological recordings of transient chopper units in response to short, best frequency, tone bursts show a brief initial period (typically < 10 ms) of rapid rate adaptation as evidenced by a rapid rise in mean interspike interval. Associated with this rate adaptation is a significant increase in firing irregularity. The changes in rate and irregularity have recently been attributed to the activation of noisy inhibitory inputs on the cell [e.g., Banks and Sachs, J. Neurophysiol. 65, 606-629 (1991)]. However, the results show that the transient chopper response pattern can be generated without the need for inhibitory inputs. The transience of the initial chopping pattern is sensitive to the following model parameters: (a) the firing threshold of the cell, (b) the number of excitatory inputs that converge on the cell, and (c) the magnitude of the current delivered to the cell for each active input. The response was also found to be relatively insensitive to changes in the degree of dendritic filtering imposed on the auditory-nerve input. The results of each simulation can be explained by considering the pattern of depolarization the cell receives during the course of a tone burst.