Elicited pontogeniculooccipital waves and phasic suppression of diaphragm activity in sleep and wakefulness.
Elicited pontogeniculooccipital waves and phasic suppression of diaphragm activity in sleep and wakefulness.
复制标题
在睡眠和清醒时引起脑桥枕波和膈肌活动的阶段性抑制。
DOI：
10.1152/jappl.1998.84.6.2106
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Pack,AI
中科院分区：
文献类型：
--
作者：
Hunt,WK;Sanford,LD;Ross,RJ;Morrison,AR;Pack,AI
分段是在快速眼动（REM）睡眠期间自发发生的膈肌活动的20- 100-ms暂停，有时与脑桥枕叶（PGO）波相关。听觉刺激可以在REM睡眠、非REM（NREM）睡眠和清醒期间引起碎裂或PGO波;然而，它们之间的相互关系尚未被研究。为了确定这两种现象是否是由REM睡眠中常见的相事件发生器产生的，我们检查了PGO波和分数，这些波和分数是由听觉刺激（音调）引起的，这些听觉刺激（音调）是由自由行为的猫跨状态引起的。音调引起PGO波和两种类型的分馏：短潜伏期分馏反应（SFR; 10- 60-ms潜伏期）和长潜伏期分馏反应（LFR; 60- 120-ms潜伏期）。在各州60-70%的试验中，PGO波和SFR都被引出，但每种波都可以单独引出。不同状态下诱发SFR的潜伏期和持续时间相似，但REM睡眠中诱发PGO波的潜伏期（平均62.5 ms）显著长于清醒或NREM睡眠。诱发SFR的持续时间比PGO波短，与自发性碎裂相反，自发性碎裂与PGO波有不同的关系，通常发生在PGO波开始后10-40 ms。LFR在REM睡眠期间最常被诱发，在其与PGO波的时间关系上类似于自发的分离，并且可能反映了对REM睡眠特征的运动神经元抑制的偏好，而不是NREM睡眠或清醒。我们的结论是，虽然PGO波和SFR共享一些功能，LFR一样，他们可能是由不同的神经元群体。在三只猫中，PGO波和分数之间没有相关性，而在一只猫中，它们与REM睡眠（LFR和SFR）和清醒（仅SFR）相关。因此，大多数证据都反对REM睡眠中存在共同的相位事件发生器。
Fractionations are 20- to 100-ms pauses in diaphragm activity that occur spontaneously during rapid-eye-movement (REM) sleep, sometimes in association with pontogeniculooccipital (PGO) waves. Auditory stimuli can elicit fractionations or PGO waves during REM sleep, non-REM (NREM) sleep, and waking; however, their interrelationship has not been investigated. To determine whether the two phenomena are produced by a common phasic-event generator in REM sleep, we examined PGO waves and fractionations that were elicited by auditory stimuli (tones) presented to freely behaving cats across states. Tones elicited PGO waves and two types of fractionations: short-latency fractionation responses (SFRs; 10- to 60-ms latencies) and long-latency fractionation responses (LFRs; 60- to 120-ms latencies). Both a PGO wave and a SFR were elicited in 60–70% of trials across states, but each could be elicited alone. The latencies and durations of elicited SFRs were similar across states, but the latencies of elicited PGO waves in REM sleep (mean 62.5 ms) were significantly longer than in waking or NREM sleep. Elicited SFRs consistently occur with shorter latencies than do PGO waves, in contrast to spontaneous fractionations, which have a variable relationship to PGO waves and usually occur 10–40 ms after the onset of the PGO wave. The LFR then, elicited most frequently during REM sleep, resembles a spontaneous fractionation in its temporal relationship to the PGO wave and may reflect the bias toward motoneuronal inhibition characterizing REM sleep but not NREM sleep or waking. We conclude that, although PGO waves and SFRs share some features, like LFRs they probably are generated by different neuronal populations. In three cats there was no correlation between PGO waves and fractionations, whereas in one cat they were associated in REM sleep (LFRs and SFRs) and waking (SFRs only). Thus the majority of evidence argues against the existence of a common phasic-event generator in REM sleep.