HUMAN-IMMUNODEFICIENCY-VIRUS AND THE BRAIN - INVESTIGATION OF VIRUS LOAD AND NEUROPATHOLOGIC CHANGES IN PRE-AIDS SUBJECTS
HUMAN-IMMUNODEFICIENCY-VIRUS AND THE BRAIN - INVESTIGATION OF VIRUS LOAD AND NEUROPATHOLOGIC CHANGES IN PRE-AIDS SUBJECTS
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DOI：
10.1093/infdis/168.4.818
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发表时间：
1993-10-01
影响因子：
6.4
通讯作者：
PEUTHERER, JF
中科院分区：
文献类型：
--
作者：
BELL, JE;BUSUTTIL, A;PEUTHERER, JF
对23名静脉注射吸毒者的脑组织进行了检查，以寻找人类免疫缺陷病毒（HIV）感染的证据，这些吸毒者在血清转换后几年突然死亡，但仍处于感染的症状前阶段。无巨细胞性脑炎，但14例表现为T淋巴细胞性软脑膜炎，3例表现为其他重要的神经病理特征。对23例中的13例进行了HIV定量聚合酶链反应，6例结果为阴性，其他7例结果为极低阳性，这一发现与脑组织中残留感染血液的污染一致。这与艾滋病感染组织中的发现形成对比，在艾滋病感染组织中发现了大量的前病毒。可以得出结论，脑组织中的显著感染不会发生在艾滋病感染的症状前阶段，并且中枢神经系统的侵袭可能会延迟，直到过渡到有症状的艾滋病。
Brain tissue was examined for evidence of human immunodeficiency virus (HIV) infection in 23 intravenous drug users who died suddenly some years after seroconversion but while still in presymptomatic stages of infection. None showed giant cell encephalitis, but 14 showed T cell lymphocytic leptomeningitis and 3 showed other significant neuropathologic features. Quantitative polymerase chain reaction for HIV was applied to 13 of the 23 with negative results in 6 and very low positive results in the other 7, a finding consistent with contamination by residual infected blood in the brain tissue. This contrasted with findings in AIDS-infected tissue, in which substantial amounts of provirus were found. It is concluded that significant infection in brain tissue does not occur in presymptomatic stages of HIV infection and that invasion of the central nervous system may be delayed until the transition to symptomatic AIDS.