Dormancy in a model of murine B cell lymphoma.
Dormancy in a model of murine B cell lymphoma.
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DOI：
10.1006/scbi.2001.0383
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发表时间：
2001-08
影响因子：
14.5
通讯作者：
J. Uhr;R. Marches
中科院分区：
文献类型：
--
作者：
J. Uhr;R. Marches
A B cell lymphoma model of dormancy in mice was established by prior immunization to the B cell membrane immunoglobulin idiotype. The antibody to the idiotype was the major factor in inducing and maintaining dormancy and acted primarily as an agonist rather than via effector functions. CD8+ T cells synergized with anti-Id in inducing dormancy by secreting IFN-gamma. Cycling in the dormant population was reduced 3-5 fold, but each mouse contained approximately 10(6) tumor cells in its spleen, some of which were cycling, during the 1.5 years of observation. Thus, replication is balanced by cell death.
