Mycoplasma pneumoniae Infection Affects the Serum Levels of Vascular Endothelial Growth Factor and Interleukin-5 in Atopic Children.
Mycoplasma pneumoniae Infection Affects the Serum Levels of Vascular Endothelial Growth Factor and Interleukin-5 in Atopic Children.
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DOI：
10.4168/aair.2012.4.2.92
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Oh JW
中科院分区：
文献类型：
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作者：
Jeong YC;Yeo MS;Kim JH;Lee HB;Oh JW
先前的研究已经概述了支原体肺炎（M。肺炎）感染可促进过敏性肺部炎症和气道重塑，并且来自人类研究的越来越多的证据表明，非典型细菌感染导致哮喘恶化、慢性哮喘和疾病严重性以及细胞因子表达的变化。本研究评价了特应性肺炎支原体肺炎患儿血清血管内皮生长因子（VEGF）和白细胞介素（IL）-5水平的变化。我们总共招募了72名肺炎儿童。患者分为4组：特应性儿童M。肺炎组（I组，n=24），非特应性肺炎患儿M.肺炎肺炎（II组，n=23）、病毒性肺炎的特应性儿童（III组，n=13）和病毒性肺炎的非特应性儿童（IV组，n=12）。采用酶联免疫吸附法测定入院时和恢复时血清IL-5、IL-13、VEGF和肿瘤坏死因子-α水平。在入院期和临床恢复期，I组血清VEGF和IL-5水平均高于其他组。在I组中，恢复期血清VEGF和IL-5水平高于入院期（VEGF：1，102.2 ±569.4 vs. 874.9±589.9 pg/mL; IL-5：150.5±63.9 vs. 120.2±46.7 pg/mL）。过敏性紫癜患儿血清VEGF和IL-5水平较M.肺炎的发病率高于其他组。恢复期血清VEGF、IL-5水平较入院时升高。本研究的结果表明，VEGF和IL-5的增加可能有助于M.肺炎感染。这些细胞因子可能通过其各自的促炎途径加重过敏状态，并在M.特应性肺炎儿童肺炎
Previous studies have outlined mechanisms by which Mycoplasma pneumonia (M. pneumonia) infection may promote allergic lung inflammation and airway remodeling, and increasing evidence from human studies suggests that atypical bacterial infections contribute to asthma exacerbation, chronic asthma, and disease severity with changes in cytokine expression. The present study evaluated changes in serum levels of vascular endothelial growth factor (VEGF) and interleukin (IL)-5 in atopic children with Mycoplasma pneumoniae pneumonia. We recruited a total of 72 children with pneumonia. The patients were divided into 4 groups: atopic children with M. pneumonia pneumonia (group I, n=24), non-atopic children with M. pneumonia pneumonia (group II, n=23), atopic children with viral pneumonia (group III, n=13), and non-atopic children with viral pneumonia (group IV, n=12). Serum levels of IL-5, IL-13, VEGF, and tumor necrosis factor-α were measured at admission and at recovery using enzyme-linked immunosorbent assays. Serum levels of VEGF and IL-5 were elevated in group I compared with the other groups at both admission phase and clinical recovery phase. In group I, serum levels of VEGF and IL-5 were higher at recovery phase than at admission phase (VEGF: 1,102.2±569.4 vs. 874.9±589.9 pg/mL, respectively; IL-5: 150.5±63.9 vs. 120.2±46.7 pg/mL, respectively). The serum levels of VEGF and IL-5 were more increased in atopic children with M. pneumonia pneumonia than in the other groups. In this group, the serum levels of VEGF and IL-5 were more increased at recovery phase than at admission phase. The results of this study suggest that increases in VEGF and IL-5 may contribute to the development of hypersensitivity during M. pneumonia infection. These cytokines may act through their respective pro-inflammatory pathways to aggravate the allergic status and induce airway hypersensitivity during M. pneumonia pneumonia in atopic children.