UBER DIE ENZYMATISCHE WIRKUNG VON INFLUENZAVIRUS
UBER DIE ENZYMATISCHE WIRKUNG VON INFLUENZAVIRUS
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DOI：
10.1515/bchm2.1955.301.1-2.235
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发表时间：
1955-01-01
影响因子：
--
通讯作者：
LEMPFRID, H
中科院分区：
文献类型：
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作者：
KLENK, E;FAILLARD, H;LEMPFRID, H
本文研究了流感病毒（Lee株）对尿粘蛋白抑制物的酶促作用。发现粘蛋白中23-53%的神经氨酸在病毒作用下被分离。含有神经氨酸的裂解产物证明与N-乙酰神经氨酸相同。用稀碱加热导致形成吡咯-α-羧酸。此外，在分裂产物中还有一些氨基酸;尚不清楚这些氨基酸是否是酶作用的结果。毫无疑问，这里获得的裂解产物与戈特沙尔克分离的产物相同，流感病毒的细胞受体与乙酰神经氨酸相同。讨论了该化合物的结构。
The enzymatic action of influenza virus (strain Lee) on urinary mucin inhibitor was investigated. It was found that 23-53% of the neuraminic acid of the mucin is split off by virus action. The neuraminic acid containing split product proved to be identical with N-acetylneuraminic acid. Heating with dilute alkali leads to the formation of pyrrole-alpha-carboxylic acid. In addition, there were some amino acids among the split products; it is not known whether these were produced as the result of enzyme action or not. There is little doubt that the split product obtained here is identical with that isolated by Gottschalk and that the cell receptors of influenza virus are identical with acetylneuraminic acid. The structure of this compound is discussed.