Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.
Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.
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DOI：
10.1007/978-1-4939-3661-8_5
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发表时间：
2016
影响因子：
--
通讯作者：
Markus von Schaewen;G. Hrebikova;A. Ploss
中科院分区：
文献类型：
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作者：
Markus von Schaewen;G. Hrebikova;A. Ploss
人肝嵌合小鼠已成为研究人类嗜肝性病原体和新药代谢及药代动力学的重要工具。在过去的几年里，基础小鼠模型的发展非常迅速。本章将讨论这些模型系统的不同应用领域及其技术挑战。
Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.