Stage and treatment variation with age in postmenopausal women with breast cancer: compliance with guidelines.
Stage and treatment variation with age in postmenopausal women with breast cancer: compliance with guidelines.
复制标题
绝经后妇女患有乳腺癌的阶段和治疗变异：符合准则。
DOI：
10.1038/sj.bjc.6601742
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发表时间：
2004-04-19
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
老年女性的乳腺癌特定死亡率保持不变，尽管年轻年龄组的死亡率有所下降，这可能是由于缺乏筛查和治疗上的差异。这项研究比较了两组绝经后妇女(55-69岁与70岁)在同一癌症网络中超过6个月的分期和治疗。总共研究了378名患者(>；70：n=167，55-69岁：n=210)。老年妇女表现出更晚期的疾病(>；70：转移/局部晚期12%，55-69岁：3%，P<；0.01)。那些可手术的癌症患者预后更差(诺丁汉预后指数(NPI)和GT；70：中位数NPI 4.4，55-69岁：4.25，P<；0.03)。这些分期差异的部分原因是年轻人群中筛查率较高。42%的老年患者使用初级内分泌治疗，而年轻患者的这一比例为3%(P<；0.001)。适合保留乳房的老年女性更有可能选择乳房切除术(乳房切除率：57.5%vs 55-69岁：20.6%，P<；0.01)。在老年患者中，结节手术的频率较低(55-69岁：6.7%无结节手术：0.5%，P<；0.01)，而且更有可能是不充分的(>；70：10.7%<；4结节切除，55-69岁：3.4%，P<；0.02)。总而言之，与年轻的绝经后妇女相比，老年妇女患上了更晚期的乳腺癌，而且接受的治疗也不那么全面。
Breast cancer-specific mortality is static in older women despite having fallen in younger age groups, possibly due to lack of screening and differences in treatment. This study compared stage and treatment between two cohorts of postmenopausal women (55–69 vs >70 years) in a single cancer network over 6 months. A total of 378 patients were studied (>70: N=167, 55–69 years: N=210). Older women presented with more advanced disease (>70: metastatic/locally advanced 12%, 55–69 years: 3%, P<0.01). Those with operable cancer had a worse prognosis (Nottingham Prognostic Index (NPI) >70: median NPI 4.4, 55–69 years: 4.25, P<0.03). These stage differences were partially explained by higher screening rates in the younger cohort. Primary endocrine therapy was used in 42% of older patients compared with 3% in the younger group (P<0.001). Older women with cancers suitable for breast conservation were more likely to choose mastectomy (>70: 57.5% mastectomy rate vs 55–69 years: 20.6%, P<0.01). Nodal surgery was less frequent in older patients (>70: 6.7% no nodal surgery, 55–69 years: 0.5%, P<0.01) and was more likely to be inadequate (>70: 10.7% <4 nodes excised, 55–69 years: 3.4%, P<0.02). In summary, older women presented with more advanced breast cancer, than younger postmenopausal women and were treated less comprehensively.
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影响因子：
8.4
作者：
Fentiman, IS;Christiaens, MR;Therasse, P
通讯作者：
Therasse, P
DOI：
10.1016/s0748-7983(98)93104-3
发表时间：
1998-12-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Mansel, R;Blamey, RW;Winstanley, J
通讯作者：
Winstanley, J
影响因子：
168.9
作者：
Tabar, L;Yen, MF;Duffy, SW
通讯作者：
Duffy, SW
影响因子：
3
作者：
Benhaim, DI;Lopchinsky, R;Tartter, PI
通讯作者：
Tartter, PI
影响因子：
9
作者：
Brenin, DR;Morrow, M;Winchester, DP
通讯作者：
Winchester, DP