Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T
Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T
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DOI：
10.1002/nbm.2960
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发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
Near, Jamie;Andersson, Jesper;Jezzard, Peter
Short-TE MRS最近被提出作为一种体内检测和定量人脑3T -氨基丁酸（GABA）的方法。在这项研究中，我们使用模拟和实验两种方法研究了3T下GABA的短te MRS测量的准确性和可重复性。对已知代谢物输入浓度的大量模拟光谱进行LCModel分析。模拟光谱采用一定范围的谱线宽度和信噪比来研究不同实验条件的影响，并使用两种不同的基线模型进行分析，以研究不准确的基线模型对GABA量化的影响。这些分析结果表明，在与枕叶皮层典型观察相对应的实验条件下，GABA浓度估计是可重复的(平均可重复性误差，
Short-TE MRS has been proposed recently as a method for the in vivo detection and quantification of -aminobutyric acid (GABA) in the human brain at 3T. In this study, we investigated the accuracy and reproducibility of short-TE MRS measurements of GABA at 3T using both simulations and experiments. LCModel analysis was performed on a large number of simulated spectra with known metabolite input concentrations. Simulated spectra were generated using a range of spectral linewidths and signal-to-noise ratios to investigate the effect of varying experimental conditions, and analyses were performed using two different baseline models to investigate the effect of an inaccurate baseline model on GABA quantification. The results of these analyses indicated that, under experimental conditions corresponding to those typically observed in the occipital cortex, GABA concentration estimates are reproducible (mean reproducibility error,