Regulation of synthesis and roles of hyaluronan in peritoneal dialysis.
Regulation of synthesis and roles of hyaluronan in peritoneal dialysis.
复制标题
DOI：
10.1155/2015/427038
复制
发表时间：
2015
影响因子：
--
通讯作者：
Sitter T
中科院分区：
文献类型：
--
作者：
Bowen T;Meran S;Williams AP;Newbury LJ;Sauter M;Sitter T
透明质酸 (HA) 是一种普遍存在的细胞外基质糖胺聚糖，由交替的 D-葡萄糖醛酸和 D-N-乙酰葡糖胺残基的重复二糖单元组成，通过交替的 β-1,4 和 β-1,3 糖苷键连接。 HA 在人体中由 HA 合酶 (HAS) 酶 1、2 和 3 合成，这些酶由相应的 HAS 基因编码。先前的体外研究表明，人类腹膜间皮细胞中，HAS 表达发生特征性变化，HA 合成增加，以响应受伤和促炎细胞因子。此外，体内模型和人体腹膜活检样本提供了目前伴随腹膜透析治疗的纤维化中HA代谢变化的证据。本综述讨论了这些已发表的观察结果以及它们如何有助于改善腹膜透析。
Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic bonds. HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes. Previous in vitro studies have shown characteristic changes in HAS expression and increased HA synthesis in response to wounding and proinflammatory cytokines in human peritoneal mesothelial cells. In addition, in vivo models and human peritoneal biopsy samples have provided evidence of changes in HA metabolism in the fibrosis that at present accompanies peritoneal dialysis treatment. This review discusses these published observations and how they might contribute to improvement in peritoneal dialysis.