IMMUNOREACTIVITY FOR P-170 GLYCOPROTEIN IN MALIGNANT MESOTHELIOMA AND IN NONNEOPLASTIC MESOTHELIUM OF THE PLEURA USING THE MURINE MONOCLONAL-ANTIBODY JSB-1
IMMUNOREACTIVITY FOR P-170 GLYCOPROTEIN IN MALIGNANT MESOTHELIOMA AND IN NONNEOPLASTIC MESOTHELIUM OF THE PLEURA USING THE MURINE MONOCLONAL-ANTIBODY JSB-1
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DOI：
10.1002/path.1711670103
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发表时间：
1992-05-01
影响因子：
7.3
通讯作者：
VANMARCK, E
中科院分区：
文献类型：
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作者：
RAMAEL, M;VANDENBOSSCHE, J;VANMARCK, E
报道了使用鼠单克隆抗体 JSB-1 对人非肿瘤性间皮（35 例）和恶性间皮瘤（33 例）中 P-170 糖蛋白免疫反应性进行免疫组织化学研究的结果。大多数恶性间皮瘤病例表现出肿瘤细胞的细胞质和膜免疫反应性。与正常间皮中不存在免疫反应性相比，这些发现非常重要。
The results of an immunohistochemical study of P-170 glycoprotein immunoreactivity in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using the murine monoclonal antibody JSB-1 are reported. The majority of malignant mesothelioma cases exhibited cytoplasmic and membrane immunoreactivity in neoplastic cells. These findings are highly significant when compared with the absence of immunoreactivity in normal mesothelium.