THE GROWING HAIR ROOTS OF THE HUMAN SCALP AND MORPHOLOGIC CHANGES THEREIN FOLLOWING AMETHOPTERIN THERAPY
THE GROWING HAIR ROOTS OF THE HUMAN SCALP AND MORPHOLOGIC CHANGES THEREIN FOLLOWING AMETHOPTERIN THERAPY
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DOI：
10.1038/jid.1957.87
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发表时间：
1957-01-01
影响因子：
6.5
通讯作者：
STEINMULLER, R
中科院分区：
文献类型：
--
作者：
VANSCOTT, EJ;REINERTSON, RP;STEINMULLER, R
用显微镜检查手动提取的头皮毛发的根部，并确定生长期（生长期）毛发与静止期（休止期）毛发的比例。正常成年人头皮中的毛大多处于生长期。肿瘤性疾病患者毛发生长比例的范围大于健康个体。生长期的毛球在氨甲喋呤治疗后出现萎缩，并暂时产生直径明显缩小的毛干。停止治疗后，球迅速恢复，并再次产生正常直径的毛干。这导致毛干的局灶性收缩。服用氨甲喋呤后的脱发是由于发干在收缩部位断裂，而不是由于头发根部脱落。
Roots of manually extracted scalp hairs were examined microscopically and the proportions of growing (anagen) hairs to resting (telogen) hairs determined. Most of the hairs in the scalps of normal adults were in the growing stage. The range in the proportions of growing hairs was greater in patients with neoplastic diseases than in healthy individuals. Anagen hair bulbs became atrophic in response to amethopterin therapy and temporarily produced a hair shaft markedly diminished in diameter. The bulb recovered promptly following cessation of therapy, and again produced a hair shaft of normal diameter. This resulted in a focal constriction of the hair shaft. Loss of hair following amethopterin is due to breaking of hair shafts at a constricted site, and is not due to hairs falling out at the roots.