Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder
Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder
复制标题
DOI：
10.1016/j.biopsych.2009.04.037
复制
发表时间：
2009-10-01
影响因子：
10.6
通讯作者：
Geracioti, Thomas D., Jr.
中科院分区：
文献类型：
--
作者：
Sah, Renu;Ekhator, Nosakhare N.;Geracioti, Thomas D., Jr.
背景资料：神经肽Y（NPY）是一种调节压力和焦虑的肽类神经递质，被认为是人类的压力恢复因子。创伤后应激障碍（PTSD）是一种与压力有关的焦虑症。我们假设，中枢神经系统神经肽Y失调的PTSD，并寻求纠正中央神经肽Y数据的disorder.Methods：我们确定了上午的神经肽Y浓度在脑脊液（CSF）从10名男性受试者慢性战斗相关的PTSD和13名健康男性。结果：与正常对照组相比，PTSD患者脑脊液神经肽Y浓度显著降低（对照组平均值为360.0 ± 17.7 pg/mL，而PTSD患者仅为233.6 ± 28.7 pg/mL [p = 0.0008]）。年龄和体重指数（BMI）的调整仍然揭示了一个非常显着的减少CSF神经肽Y在PTSD组（p = 0.003）。结论：男性与战斗相关的PTSD有低CSF浓度的假定弹性激素神经肽Y，可能与疾病或极端压力暴露本身。
Background: Neuropeptide Y (NPY), a peptide neurotransmitter that regulates stress and anxiety, has been proposed to be a stress resilience factor in humans. Posttraumatic stress disorder (PTSD) is a stress-related anxiety disorder. We hypothesized that central nervous system NPY is dysregulated in PTSD and sought to redress the absence of central NPY data in the disorder.Methods: We determined morning NPY concentrations in cerebrospinal fluid (CSF) from 10 male subjects with chronic combat-related PTSD and from 13 healthy men. Neuropeptide Y-like immunoreactivity was measured by enzyme immunoassay (EIA).Results: As compared with the normal comparison subjects, PTSD patients had significantly lower concentrations of CSF neuropeptide Y (mean CSF NPY was 360.0 +/- 17.7 pg/mL in control subjects but only 233.6 +/- 28.7 pg/mL in PTSD patients [p = .0008]). Adjustments for age and body mass index (BMI) still revealed a highly significant reduction in CSF NPY in the PTSD group (p = .003).Conclusions: Men with combat-related PTSD have low CSF concentrations of the putative resiliency hormone NPY, possibly related to the disorder or to extreme stress exposure per se.