The endothelin-parathyroid hormone-related protein vasoactive peptide system in human endometrium: modulation by transforming growth factor-beta.
The endothelin-parathyroid hormone-related protein vasoactive peptide system in human endometrium: modulation by transforming growth factor-beta.
复制标题
人子宫内膜内皮素-甲状旁腺激素相关蛋白血管活性肽系统：通过转化生长因子-β进行调节。
DOI：
10.1093/humrep/11.suppl_2.62
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
MacDonald,PC
中科院分区：
文献类型：
--
作者：
Casey,ML;MacDonald,PC
内皮素-1 （ET-1）是一种有效的血管收缩剂，甲状旁腺激素相关蛋白（PTH-rP）是一种有效的血管松弛剂，存在并合成于人子宫内膜。人类子宫内膜基质细胞中这些血管活性肽的产生受性类固醇激素的调节。此外，降解ET-1的中性内肽酶24.11（也称为脑啡肽酶）在子宫内膜基质细胞中表达，该酶的水平（mRNA、蛋白和比活性）随着孕酮/孕激素的作用而升高。性类固醇激素对人子宫内膜血管活性肽形成和作用的调节被认为在调节螺旋动脉张力/血流中起关键作用，从而导致子宫内膜出血，无论是黄体酮诱导的还是自然发生的。ET-1、PTH-rP和脑啡肽酶的表达受转化生长因子-β的调控。我们推测，在合成黄体酮给药过程中，子宫内膜基质细胞中ET-1、脑啡肽酶和PTH-rP的不适当表达可能是导致子宫内膜发育异常和子宫内膜不规则出血的原因之一。
Endothelin-1 (ET-1), a potent vasoconstrictor, and parathyroid hormone-related protein (PTH-rP), a potent vasorelaxant, are present and synthesized in human endometrium. The production of these vasoactive peptides in stromal cells of the human endometrium is modulated by sex steroid hormones. In addition, neutral endopeptidase 24.11 (also called enkephalinase), which degrades ET-1, is expressed in the stromal cells of the endometrium, and the levels of this enzyme (mRNA, protein and specific activity) are increased in response to progesterone/progestin. The sex steroid hormone-mediated regulation of vasoactive peptide formation and action in the human endometrium is believed to serve a key role in modulating spiral artery tone/blood flow, and thus endometrial bleeding, whether progestin induced or naturally occurring. Moreover, the expression of ET-1, PTH-rP and enkephalinase is modulated by transforming growth factor-β. We hypothesize that the inappropriate expression of ET-1, enkephalinase and PTH-rP in endometrial stromal cells during synthetic progestin administration may be one cause of abnormal endometrial development and erratic endometrial bleeding.