REPROGRAMMING CELL FATE IN THE DEVELOPING DROSOPHILA RETINA - TRANSFORMATION OF R7-CELLS BY ECTOPIC EXPRESSION OF ROUGH
REPROGRAMMING CELL FATE IN THE DEVELOPING DROSOPHILA RETINA - TRANSFORMATION OF R7-CELLS BY ECTOPIC EXPRESSION OF ROUGH
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DOI：
10.1101/gad.4.5.728
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发表时间：
1990-05-01
影响因子：
10.5
通讯作者：
HAFEN, E
中科院分区：
文献类型：
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作者：
BASLER, K;YEN, D;HAFEN, E
在果蝇发育中的眼睛中，同源盒基因Rough在发育中的感光细胞R2和R5中是相邻的R3和R4细胞正确发育所必需的。我们已经表达了粗糙异位在一个有限的子集的发展小眼细胞使用sevenless增强。在假定的R7细胞中表达粗糙蛋白将该细胞转化为R1-6型光感受器。这种转化是细胞自主的，与粗糙突变体表型的明显非自主性相反，并且取决于sevenless基因的存在。我们建议，在野生型，粗糙的功能自主的规格R2/5感光细胞的身份，但本身不能启动神经发育。
In the developing eye of Drosophila, the homeo box gene rough is required in the developing photoreceptor cells R2 and R5 for the correct development of the neighboring R3 and R4 cells. We have expressed rough ectopically in a limited subset of developing ommatidial cells using the sevenless enhancer. Expression of rough in the presumptive R7 cell transforms this cell into an R1-6 type photoreceptor. This transformation is cell autonomous in contrast to the apparent nonautonomy of the rough mutant phenotype and depends on the presence of the sevenless gene. We propose that in wild type, rough functions autonomously in the specification of R2/5 photoreceptor cell identity but by itself cannot initiate neural development.