Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4
Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4
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酪氨酸和二苯甲酮 4 的氯化产物的综合遗传毒性。
DOI：
10.1016/j.jhazmat.2016.10.014
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发表时间：
2017-01-15
影响因子：
13.6
通讯作者：
Qu, Jiuhui
中科院分区：
文献类型：
--
作者：
Chang, Yangyang;Bai, Yaohui;Qu, Jiuhui
研究了单一前体消毒副产物的毒性。在这里，我们研究了遗传毒性时，两个前体（酪氨酸（Tyr）和二苯甲酮-4（BP-4））一起氯化和单独氯化。我们试图检查是否可以估计的遗传毒性的混合物（GCM）的遗传毒性的总和的个别前体（GCI），这是分别氯化。我们使用SOS/umu测试确定遗传毒性。结果表明，GCM与GCI并不完全相同。GCM和GCI的遗传毒性差异（G（Delta））随pH的升高而减小，在pH 5.0-6.1范围内，GCM的遗传毒性高于GCI（G（Delta）> 0），而GCI的遗传毒性低于GCM（G（Delta）> 0）。
The toxicity of disinfection by-products (DBPs) from a single precursor was studied intensively. Here we examined the genotoxicity when two precursors (tyrosine (Tyr) and benzophenone-4 (BP-4)) were chlorinated together and separately. We sought to examine whether the genotoxicity of the mixture (GCM) could be estimated from the sum of the genotoxicities of the individual precursors (GCI), which were chlorinated separately. We determined the genotoxicity using the SOS/umu test. The results revealed that GCM was not identical to GCI. The difference in genotoxicity between GCM and GCI (G(Delta)) was observed to decrease with increasing pH. GCM was higher than GCI (G(Delta) > 0) at pH 5.0-6.1, and lower than GCI (G(Delta)