Neonicotinoids - from zero to hero in insecticide chemistry
Neonicotinoids - from zero to hero in insecticide chemistry
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DOI：
10.1002/ps.1631
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发表时间：
2008-11-01
影响因子：
4.1
通讯作者：
Nauen, Ralf
中科院分区：
文献类型：
--
作者：
Jeschke, Peter;Nauen, Ralf
近年来，类烟碱类杀虫剂已成为现代作物保护中增长最快的一类杀虫剂，广泛用于对付各种吸吮和某些咀嚼害虫。作为有效的激动剂，它们选择性地作用于昆虫烟碱乙酰胆碱受体，其分子靶位点。烟碱类化合物的发现是杀虫剂研究中的一个里程碑，极大地促进了对昆虫烟碱乙酰胆碱受体功能特性的理解。由于对非靶标生物和环境的风险相对较低，类烟碱杀虫剂的靶标特异性较高，而且在施用方法上具有多样性，因此必须在全球范围内维持这一重要类别，以便制定综合虫害管理战略和昆虫抗药性管理方案。本文综述了烟碱类杀虫剂的来源、结构、成键及相关性质。(c)2008年化学工业协会
In recent years, neonicotinoids have been the fastest-growing class of insecticides in modern crop protection, with widespread use against a broad spectrum of sucking and certain chewing pests. As potent agonists, they act selectively on insect nicotinic acetylcholine receptors, their molecular target site. The discovery of neonicotinoids can be considered as a milestone in insecticide research and facilitates greatly the understanding of the functional properties of insect nicotinic acetylcholine receptors. Because of the relatively low risk for nontarget organisms and environment, the high target specificity of neonicotinoid insecticides and their versatility in application methods, this important class has to be maintained globally for integrated pest management strategies and insect resistance management programmes. This review comprehensively describes particularly the origin, structure and bonding as well as associated properties of neonicotinoid insecticides. (c) 2008 Society of Chemical Industry