Alcohol-induced cardiac hemodynamic and Ca2+ flux dysfunctions are reversible.
Alcohol-induced cardiac hemodynamic and Ca2+ flux dysfunctions are reversible.
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酒精引起的心脏血流动力学和 Ca2+ 通量功能障碍是可逆的。
DOI：
10.1016/0022-2828(81)90262-5
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发表时间：
1981
影响因子：
5
通讯作者：
D. Mason
中科院分区：
文献类型：
--
作者：
L. D. Segel;S. Rendig;D. Mason
在对照组大鼠、连续10个月饮酒占每日热量39%的大鼠和戒酒一段时间后的酒精大鼠中研究了心脏血流动力学功能和心肌肌浆网膜囊泡的钙积累，以确定酒精诱导的改变是否可逆。采用离体工作全心准备评估心脏泵功能。酒精性大鼠心脏对拟交感神经药物多巴酚丁胺（0.1 μ m）的反应性降低，左心室收缩压峰值、d P d tmax、主动脉血流量峰值和− d P d tmax均降低。酒精从饮食中撤出4至6个月后，心脏血流动力学反应多巴酚丁胺与对照组无显着差异。酒精性大鼠Ca 2+结合和摄取明显低于对照组.戒酒后4 ~ 6个月，钙结合和摄取恢复到对照组水平。数据表明，长期饮酒导致心脏损害，其特征在于心脏不能完全响应β-肾上腺素能刺激。这种肾上腺素能亚敏感性可能至少部分是由细胞内Ca 2+流介导的舒张和兴奋-收缩偶联的缺陷引起的。这些缺陷是可逆的，因为心脏泵功能和钙积累在戒酒后恢复正常。
Cardiac hemodynamic function and calcium accumulation by cardiac sarcoplasmic reticulum membrane vesicles were studied in control rats, in rats that had consumed alcohol as 39% of their daily calories for 10 months, and in alcoholic rats after a period of withdrawal from alcohol to determine if alcohol-induced alterations were reversible. Cardiac pump function was assessed with an isolated working whole heart preparation. Alcoholic rat hearts exhibited decreased response of left ventricular peak systolic pressure, d P d t max, peak aortic flow, and− d P d t max to challenge with the sympathomimetic agent, dobutamine (0.1 μ m). After alcohol was withdrawn from the diet for 4 to 6 months, cardiac hemodynamic response to dobutamine was not significantly different from controls. In alcoholic rats, Ca 2+ binding and uptake were significantly lower than in controls. Four to six months following withdrawal of alcohol, Ca 2+ binding and uptake had returned to control values. The data indicate that chronic alcohol consumption results in cardiac impairment characterized by inability of the heart to fully respond to β-adrenergic stimulation. This adrenergic subsensitivity may be caused, at least in part, by defect (s) in relaxation and excitation-contraction coupling mediated by intracellular Ca 2+ fluxes. These defects were reversible since cardiac pump function and calcium accumulation returned to normal after withdrawing alcohol.