THE STRENGTH OF THE GENETIC EFFECT - IS THERE ROOM FOR AN ENVIRONMENTAL INFLUENCE IN THE ETIOLOGY OF SCHIZOPHRENIA
THE STRENGTH OF THE GENETIC EFFECT - IS THERE ROOM FOR AN ENVIRONMENTAL INFLUENCE IN THE ETIOLOGY OF SCHIZOPHRENIA
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DOI：
10.1192/bjp.164.5.593
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发表时间：
1994-05-01
影响因子：
10.5
通讯作者：
FARMER, A
中科院分区：
文献类型：
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作者：
MCGUFFIN, P;ASHERSON, P;FARMER, A
精神分裂症与基因有关的证据是令人信服的。然而，遗传模式是复杂的，人们通常认为环境因素也有最终将被识别的作用。我们认为情况并不一定是这样。虽然将遗传素质和环境压力结合在一起的假设是不能反驳的，但也有可能“非遗传”因素完全由影响基因表达或结构的随机事件组成。
The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that 'non-genetic' factors consist entirely of stochastic events affecting gene expression or structure.