Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome.
Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome.
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降低强度调理后的同种异体造血干细胞移植治疗蕈样肉芽肿和塞扎里综合征。
DOI：
10.1002/hon.2162
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发表时间：
2014
期刊：
影响因子：
3.3
通讯作者：
Teshima T.
中科院分区：
文献类型：
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作者：
Shiratori S;Fujimoto K;Nishimura M;Hatanaka KC;Kosugi-Kanaya M;Okada K;Sugita J;Shigematsu A;Hashimoto D;Endo T;Kondo T;Abe R;Hashino S;Matsuno Y;Shimizu H;Teshima T.
晚期蕈样真菌病和seary综合征（MF/SS）预后较差。同种异体造血干细胞移植（HSCT），特别是使用低强度调节（RIC）方案，是治疗晚期MF/SS的一种有希望的治疗方法。我们对9例晚期MF/SS患者进行了RIC‐HSCT。移植后中位随访时间为954天，估计3年总生存率为85.7%(95%置信区间，33.4-97.9%)，无复发死亡率。5例患者在RIC - HSCT后复发；然而，在4例仅从皮肤检测到复发的患者中，1例患者实现了持续的完全缓解，另外3例患者通过逐渐减少免疫抑制剂和供体淋巴细胞输注，疾病得到了控制，这表明移植抗淋巴瘤效应和HSCT从晚期到早期的“降低分期”效应改善了晚期MF/SS的预后。这些结果表明RIC - HSCT是晚期MF/SS的有效治疗方法。版权所有©2014 John Wiley & Sons， Ltd。
Advanced‐stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced‐intensity conditioning (RIC) regimen, is a promising treatment for advanced‐stage MF/SS. We performed RIC‐HSCT in nine patients with advanced MF/SS. With a median follow‐up period of 954 days after HSCT, the estimated 3‐year overall survival was 85.7% (95% confidence interval, 33.4–97.9%) with no non‐relapse mortality. Five patients relapsed after RIC‐HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft‐versus‐lymphoma effect and ‘down‐staging’ effect from advanced stage to early stage by HSCT improve the prognosis of advanced‐stage MF/SS. These results suggest that RIC‐HSCT is an effective treatment for advanced MF/SS. Copyright © 2014 John Wiley & Sons, Ltd.