Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.
Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.
复制标题
DOI：
10.3390/jcdd10090381
复制
发表时间：
2023-09-06
影响因子：
2.4
通讯作者：
Pediatric Heart Network MINDS Neuroimaging Ancillary Study Investigators
中科院分区：
文献类型：
--
作者：
Panigrahy A;Schmithorst V;Ceschin R;Lee V;Beluk N;Wallace J;Wheaton O;Chenevert T;Qiu D;Lee JN;Nencka A;Gagoski B;Berman JI;Yuan W;Macgowan C;Coatsworth J;Fleysher L;Cannistraci C;Sleeper LA;Hoskoppal A;Silversides C;Radhakrishnan R;Markham L;Rhodes JF;Dugan LM;Brown N;Ermis P;Fuller S;Cotts TB;Rodriguez FH;Lindsay I;Beers S;Aizenstein H;Bellinger DC;Newburger JW;Umfleet LG;Cohen S;Zaidi A;Gurvitz M;Pediatric Heart Network MINDS Neuroimaging Ancillary Study Investigators
先天性心脏病（CHD）治疗的巨大进步使成人期生存率从20世纪60年代的不到10%提高到目前的90%以上，因此成人CHD （ACHD）患者现在超过了儿科患者。ACHD患者表现出与生活质量下降相关的特定领域的神经认知缺陷，包括受教育程度和社会交往方面的缺陷。我们的假设是，ACHD患者表现出血管性脑损伤和脑结构/生理改变，这些改变可以预测特定的神经认知缺陷，而认知储备的行为和环境富集代理（例如教育水平和生活方式/社会习惯）可以改变这些缺陷。本技术说明描述了国家心肺血液研究所（NHLBI）资助的儿科心脏网络（PHN）的一项辅助研究“成人先天性心脏病（ACHD）的多机构神经认知发现研究（MINDS）”。利用来自母体研究的临床、神经心理学和生物标本数据，我们的研究将提供神经认知结果的结构-生理相关性，这是首个在ACHD患者中进行的多中心神经影像学研究。该研究的局限性包括辅助研究固有的招募挑战、植入式心脏装置和神经成像生物标志物的协调。这项研究的结果将有助于塑造ACHD患者的护理，并进一步了解脑损伤与认知储备之间的相互作用。
Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve.
登录
查看更多内容
影响因子：
4.1
作者：
Schmithorst VJ;Adams PS;Badaly D;Lee VK;Wallace J;Beluk N;Votava-Smith JK;Weinberg JG;Beers SR;Detterich J;Wood JC;Lo CW;Panigrahy A
通讯作者：
Panigrahy A
DOI：
10.1017/s1355617714001027
发表时间：
2015-01
期刊：
Journal of the International Neuropsychological Society : JINS
影响因子：
--
作者：
Cassidy AR;White MT;DeMaso DR;Newburger JW;Bellinger DC
通讯作者：
Bellinger DC
影响因子：
4.2
作者：
Cordina, Rachael;Grieve, Stuart;Barnett, Michael;Lagopoulos, Jim;Malitz, Nathan;Celermajer, David S.
通讯作者：
Celermajer, David S.
影响因子：
1
作者：
Bellinger, David C.;Newburger, Jane W.;Rappaport, Leonard A.
通讯作者：
Rappaport, Leonard A.
DOI：
10.1080/13803395.2016.1204992
发表时间：
2017-01-01
影响因子：
2.2
作者：
Contador, Israel;del Ser, Teodoro;Bermejo-Pareja, Felix
通讯作者：
Bermejo-Pareja, Felix