Asymptomatic and symptomatic cryptosporidiosis: Their acute effect on weight gain in Peruvian children
Asymptomatic and symptomatic cryptosporidiosis: Their acute effect on weight gain in Peruvian children
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DOI：
10.1093/oxfordjournals.aje.a009086
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发表时间：
1997-01-15
影响因子：
5
通讯作者：
Sterling, CR
中科院分区：
文献类型：
--
作者：
Checkley, W;Gilman, RH;Sterling, CR
这项研究调查了儿童首次感染微小隐孢子虫是否对体重增加产生急性影响。具体而言，作者比较了微小隐孢子虫感染和未感染儿童的每月体重增加率。在两年的时间里（1989-1991），对招募时年龄为 0-3 个月的秘鲁儿童进行了每周两次的随访，以评估每日腹泻状况，每周进行一次微小念珠菌粪便检查，每月进行一次人体测量。 207 名儿童的数据使作者能够检查微小念珠菌感染对体重增加的影响。在为期 2 年的研究期间，45% (94/207) 的儿童首次感染微小念珠菌。 94 名感染儿童中有 57 名的体重增加区间符合分析标准，其中 63% (36/57) 无症状（即没有腹泻），平均而言，有症状的隐孢子虫病儿童在感染第一个月期间比尚未感染的无腹泻儿童体重增加（即生长）少 342 克（95% 置信区间 167-517）， 无症状隐孢子虫病的影响不太严重：平均而言，无症状感染儿童在感染第一个月内比未感染且无腹泻的儿童体重减少 162 克（95% 置信区间 27-297）。有症状的隐孢子虫病比无症状的隐孢子虫病更能抑制体重增加，但后者的发生率是无症状的隐孢子虫病的两倍。由于无症状的隐孢子虫病更为普遍，因此与有症状的隐孢子虫病相比，它对社区儿童生长的总体不利影响可能更大。
This study investigated whether a child's first infection with Cryptosporidium parvum had an acute effect on weight gain, Specifically, the authors compared monthly rates of weight gain between C. parvum-infected and noninfected children. Over a 2-year period (1989-1991), a cohort of Peruvian children aged 0-3 months at recruitment were followed twice weekly for assessment of daily diarrheal status, weekly for C. parvum stool examinations, and monthly for anthropometric measurements. Data on 207 children permitted the authors to examine the effect of C. parvum infection on weight gain, During the 2-year study period, 45% (94/207) of the children became infected with C. parvum for the first time. Weight gain intervals in 57 of the 94 infected children met criteria for analysis, Of these, 63 percent (36/57) were asymptomatic (i.e., had no diarrhea), On average, children with symptomatic cryptosporidiosis gained (i.e., grew) 342 g less (95% confidence interval 167-517) during the first month of infection than did children without diarrhea who were not yet infected, The effect of asymptomatic cryptosporidiosis was less severe: On average, children with asymptomatic infection gained 162 g less (95% confidence interval 27-297) during the first month of infection than did children without diarrhea who were not yet infected. Symptomatic cryptosporidiosis retarded weight gain more than did asymptomatic cryptosporidiosis, but the latter was twice as common. Since asymptomatic cryptosporidiosis is more prevalent, it may have more of an overall adverse effect on child growth in the community than symptomatic cryptosporidiosis.