The Gut-Lung Axis in Respiratory Disease
The Gut-Lung Axis in Respiratory Disease
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DOI：
10.1513/annalsats.201503-133aw
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发表时间：
2015-11-01
影响因子：
8.3
通讯作者：
Gollwitzer, Eva S.
中科院分区：
文献类型：
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作者：
Marsland, Benjamin J.;Trompette, Aurelien;Gollwitzer, Eva S.
宿主与微生物的相互作用塑造了局部细胞功能、免疫反应，并可能影响疾病的发展。有证据表明，宿主-微生物相互作用的影响远远超出了局部环境，从而影响了外周组织的反应。我们身体的粘膜组织之间存在重要的串扰，例如呼吸道疾病期间的肠道并发症，反之亦然。虽然，从机制上讲，这种现象仍然没有得到很好的定义，肠-肺轴的存在及其在健康和疾病中的意义可能对疾病病因学和治疗都非常重要。在这篇综述中，我们强调了肠道微环境的变化，特别是肠道微生物群，对呼吸系统疾病的影响。
Host-microorganism interactions shape local cell functionality, immune responses, and can influence disease development. Evidence indicates that the impact of host-microbe interactions reaches far beyond the local environment, thus influencing responses inperipheral tissues. There is a vital cross-talk between the mucosal tissues of our body, as exemplified by intestinal complications during respiratory disease and vice versa. Although, mechanistically, this phenomenon remains poorly defined, the existence of the gut-lung axis and its implications in both health and disease could be profoundly important for both disease etiology and treatment. In this review, we highlight how changes in the intestinal microenvironment, with a particular focus on the intestinal microbiota, impact upon respiratory disease.