Modeling biomedical experimental processes with OBI.
Modeling biomedical experimental processes with OBI.
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DOI：
10.1186/2041-1480-1-s1-s7
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发表时间：
2010-06-22
影响因子：
1.9
通讯作者：
OBI consortium
中科院分区：
文献类型：
--
作者：
Brinkman RR;Courtot M;Derom D;Fostel JM;He Y;Lord P;Malone J;Parkinson H;Peters B;Rocca-Serra P;Ruttenberg A;Sansone SA;Soldatova LN;Stoeckert CJ Jr;Turner JA;Zheng J;OBI consortium
实验描述通常以自由文本形式存储，未使用标准化术语，这在比较、重现和分析方面带来了挑战。这些困难对数据交换和信息检索造成了限制。
生物医学研究本体（OBI）是一项全球性的跨领域成果，它提供了一种资源，能在一个明确的综合框架内呈现生物医学研究。在此我们详细介绍OBI的三个实际应用，提供详细的建模信息并解释如何使用OBI。
我们展示了OBI如何应用于不同的生物医学研究，既能促进对实验过程的理解，又能提高语义网内的计算处理和整合能力。所涉及实体的逻辑定义使计算机能够明确无误地理解和整合不同的生物实验过程及其相关组件。
OBI可在http://purl.obolibrary.org/obo/obi/2009 - 11 - 02/obi.owl获取。
Experimental descriptions are typically stored as free text without using standardized terminology, creating challenges in comparison, reproduction and analysis. These difficulties impose limitations on data exchange and information retrieval. The Ontology for Biomedical Investigations (OBI), developed as a global, cross-community effort, provides a resource that represents biomedical investigations in an explicit and integrative framework. Here we detail three real-world applications of OBI, provide detailed modeling information and explain how to use OBI. We demonstrate how OBI can be applied to different biomedical investigations to both facilitate interpretation of the experimental process and increase the computational processing and integration within the Semantic Web. The logical definitions of the entities involved allow computers to unambiguously understand and integrate different biological experimental processes and their relevant components. OBI is available at http://purl.obolibrary.org/obo/obi/2009-11-02/obi.owl