Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
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DOI：
10.3945/ajcn.2009.27781
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发表时间：
2009-10-01
影响因子：
7.1
通讯作者：
van der Schouw, Yvonne T.
中科院分区：
文献类型：
--
作者：
Bauer, Florianne;Elbers, Clara C.;van der Schouw, Yvonne T.
背景：新的基因位点，其中大部分在大脑中表达，最近被报道与肥胖的发生有关。大脑，尤其是下丘脑，强烈参与调节体重和食物摄入量。目的：我们调查了最近报道的肥胖基因是否与腹部肥胖的测量有关，以及这些变异是否影响饮食能量或大量营养素的摄入。设计：我们研究了欧洲癌症与营养前瞻性调查(EPIC)中的1700名荷兰女性参与者。他们的人体测量和大量营养素的摄入量是可用的。采用Kaspar化学法进行基因分型。结果：有7个单核苷酸多态性(SNPs)与体重、体重指数(BMI)和腰围(未调整BMI)相关(P<；0.05)。它们位于或接近6个基因座：FTO、MC4R、KCTD15、MTCH2、NEGR1和BDNF。有5个SNP与膳食摄入量相关(P<；0.05)，位于或接近5个基因座：SH2B1(特别是脂肪增加)、KCTD15(特别是碳水化合物摄入量)、MTCH2、NEGR1和BDNF。结论：我们证实了新发现的与荷兰健康女性人群普遍肥胖有关的肥胖基因座的部分结果。我们的结果表明，这些基因座与腹部肥胖症没有特别的关联，但更普遍地与肥胖有关。我们还发现，一些SNP与特定于常量营养素的食物摄入量有关。AM J Clin Nutr 2009；90：951-9。
Background: New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake.Objectives: We investigated whether the recently reported obesity loci are associated with measures of abdominal adiposity and whether these variants affect dietary energy or macronutrient intake.Design: We studied 1700 female Dutch participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Their anthropometric measurements and intake of macronutrients were available. Genotyping was performed by using KASPar chemistry. A linear regression model, with an assumption of an additive effect, was used to analyze the association between genotypes of 12 single nucleotide polymorphisms (SNPs) and adiposity measures and dietary intake.Results: Seven SNPs were associated (P < 0.05) with weight, body mass index (BMI), and waist circumference (unadjusted for BMI). They were in or near to 6 loci: FTO, MC4R, KCTD15, MTCH2, NEGR1, and BDNF. Five SNPs were associated with dietary intake (P < 0.05) and were in or near 5 loci: SH2B1 (particularly with increased fat), KCTD15 (particularly with carbohydrate intake), MTCH2, NEGR1, and BDNF.Conclusions: We confirmed some of the findings for the newly identified obesity loci that are associated with general adiposity in a healthy Dutch female population. Our results suggest that these loci are not specifically associated with abdominal adiposity but more generally with obesity. We also found that some of the SNPs were associated with macronutrient-specific food intake. Am J Clin Nutr 2009;90:951-9.