EFFECT OF DIETARY SUCROSE AND STARCH ON ORAL GLUCOSE TOLERANCE AND INSULIN-LIKE ACTIVITY.
EFFECT OF DIETARY SUCROSE AND STARCH ON ORAL GLUCOSE TOLERANCE AND INSULIN-LIKE ACTIVITY.
复制标题
膳食蔗糖和淀粉对口服葡萄糖耐量和胰岛素样活性的影响。
DOI：
10.1152/ajplegacy.1964.206.1.105
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发表时间：
1964
期刊：
影响因子：
--
通讯作者：
A. Teitelbaum
中科院分区：
文献类型：
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作者：
A. Cohen;A. Teitelbaum
用蔗糖代替淀粉，同时保持饮食中的脂肪、蛋白质、盐和维生素恒定，导致大鼠口服葡萄糖耐量受损。产生耐受性受损所需的时间随饮食中蔗糖的百分比而变化。在饲喂含有 67% 蔗糖的饮食的动物中，这需要 21-40 天，而在饲喂含有 40% 或 33% 蔗糖的饮食的大鼠中，则分别需要 40 和 100 天。如果动物重新接受淀粉饮食，这种损害是可逆的，但当他们重新喂食蔗糖饮食时，只需要几天的时间就可以重新恢复受损的耐受性。在以淀粉形式喂养碳水化合物的动物和以动物饲料喂养的动物之间没有发现差异。蔗糖喂养的动物表现出耐受性受损，肝脏中的脂肪较多，血清中的胰岛素样活性降低。
Substituting sucrose for starch, while keeping the fat, protein, salts, and vitamins of the diet constant, resulted in impaired oral glucose tolerance in rats. The time needed to develop impaired tolerance varied with the percentage of sucrose in the diet. In animals fed a diet containing 67% sucrose this took 21–40 days, whereas in rats fed diets with 40 or 33% sucrose, it took 40 and 100 days, respectively. This impairment was reversible if the animals were put back on starch diets, but only a few days were then required to redevelop the impaired tolerance when they were refed the sucrose diet. No difference was found between animals fed carbohydrates as starch and those fed the animal stock diet. Sucrose-fed animals showing an impaired tolerance had more fat in the liver and reduced insulin-like activity in the serum.