miR-129-5p suppresses breast cancer proliferation by targeting CBX4
miR-129-5p suppresses breast cancer proliferation by targeting CBX4
复制标题
miR-129-5p 通过靶向 CBX4 抑制乳腺癌增殖。
DOI：
10.4149/neo_2018_170814n530
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发表时间：
2018-01-01
期刊：
影响因子：
3
通讯作者：
Cao, X. C.
中科院分区：
文献类型：
--
作者：
Meng, R.;Fang, J.;Cao, X. C.
microRNA（miRNA）的失调与癌症的发生和发展密切相关。我们先前的研究发现miR-129- 5 p抑制乳腺癌细胞的增殖和转移。在此，我们确定CBX 4是miR-129- 5 p靶基因。CBX 4在乳腺癌组织中上调，虽然其过表达促进细胞增殖，但其敲低抑制乳腺癌细胞的细胞增殖。此外，CBX 4介导miR-129- 5 p诱导的细胞增殖抑制，并与miR-129- 5 p表达呈负相关。这些综合结果表明，CBX 4是乳腺癌细胞中的癌基因，它可能为乳腺癌治疗提供一种新的治疗策略。
Deregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study identified that miR-129-5p suppresses proliferation and metastasis in breast cancer cells. Herein, we determined that CBX4 is a miR-129-5p target gene. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. These combined results suggest that CBX4 is an oncogene in breast cancer cells, and that it may provide a novel therapeutic strategy for breast cancer treatment.