Activating antibacterial effect of 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles by reducing their sizes
Activating antibacterial effect of 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles by reducing their sizes
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通过减小 4,6-二氨基-2-嘧啶硫醇修饰的金纳米颗粒的尺寸来激活其抗菌效果。
DOI：
10.1002/anie.202008584
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Xingyu Jiang
中科院分区：
文献类型：
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作者：
Yangzhouyun Xie;Junchuang Yang;Jiangjiang Zhang;Wenfu Zheng;Xingyu Jiang
充分修饰的金纳米粒子（GNP）对多重耐药（MDR）细菌具有优异的抗生素活性。表现出革兰氏选择性抗菌作用的纳米颗粒有利于精准治疗。在这里，我们提出了一种通过调整小分子（4,6-二氨基-2-嘧啶硫醇，DAPT）修饰的 GNP（DAPT-GNP，DGNP）的大小来调整其抗菌谱的策略。与没有抗菌作用或仅针对革兰氏阴性（G−）细菌的大型（直径约 14 nm）DGNP（lDGNP）和中型（直径 3–4 nm）DGNP（mDGNP）相比，超小型 DGNP（uDGNP，<2 nm）具有广泛的抗菌谱，特别是对细菌的抗菌功效提高了 60 倍以上。革兰氏阳性 (G+) 细菌。此外，uDGNPs 功能化支架（琼脂糖凝胶）可以作为治疗烧伤感染的通用伤口敷料。我们的策略对于探索纳米材料的特性及其应用具有深刻的洞察力。
Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug‐resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6‐diamino‐2‐pyrimidinethiol, DAPT)‐modified GNPs (DAPT‐GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (lDGNPs) and medium‐sized (3–4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram‐negative (G−) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60‐fold increase in antibacterial efficacy against Gram‐positive (G+) bacteria. Moreover, the uDGNPs‐functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nanomaterials and their applications.