Highly Potent Chiral Labeling Reagents for the Discrimination of Chiral Alcohols
Highly Potent Chiral Labeling Reagents for the Discrimination of Chiral Alcohols
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用于区分手性醇的高效手性标记试剂
DOI：
10.2116/analsci.19.1243
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发表时间：
2003
影响因子：
1.6
通讯作者：
H. Ohrui
中科院分区：
文献类型：
--
作者：
Kei Imaizumi;Hanae Terasima;K. Akasaka;H. Ohrui
合成了高灵敏的手性标记试剂(1 R，2 R)-和(1 S，2 S)-2-(2，3-anthracenedicarboximido)cyclohexanecarboxylic酸[(1 R，2 R)-和(1 S，2 S)-A]和(1 R，2 R)-和(1 S，2 S)-2-(2，3-naphthalenedicarboximido)cyclohexanecarboxylic酸[(1 R，2 R)-和(1 S，2 S)-A‘])。试剂A使我们能够通过1H核磁共振区分直链脂肪醇的对映体直到C9甲基支化，而试剂A和A‘都允许通过荧光检测的反相高效液相在10^-15摩尔水平上至多C16甲基支化。
Highly sensitive chiral labeling reagents, (1 R ,2 R )- and (1 S ,2 S )-2-(2,3-anthracenedicarboximido)cyclohexanecarboxylic acids [(1 R ,2 R )- and (1 S ,2 S )- A ] and (1 R ,2 R )- and (1 S ,2 S )-2-(2,3-naphthalenedicarboximido)cyclohexanecarboxylic acids [(1 R ,2 R )- and (1 S ,2 S )- A ′], were prepared. Reagent A has enabled us to discriminate the enantiomers of anteiso fatty alcohols up to C9 methyl branching by 1H NMR, and both reagents A and A ′have allowed up to C16 methyl branching at the 10^–15 molar level by fluorescence detected reversed-phase HPLC.