Heat dissipation of hybrid iron oxide-gold nanoparticles in an agar phantom
Heat dissipation of hybrid iron oxide-gold nanoparticles in an agar phantom
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DOI：
10.4172/2157-7439.1000335
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
A. Curtis;Maryam Malekigorji;J. Holman;M. Skidmore;Clare Hoskins
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文献类型：
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作者：
A. Curtis;Maryam Malekigorji;J. Holman;M. Skidmore;Clare Hoskins
氧化铁-金杂化纳米颗粒(HNPs)作为肿瘤消融剂和靶向药物释放的热开关在癌症治疗中具有潜在的应用前景。热产生是通过利用金涂层的表面等离子体共振产生的，这种共振通常发生在最大的紫外吸收波长处。然而，这种波长的激光通常价格昂贵，而且高度专业化。在这里，我们报道了利用相对便宜的Ng：YAG1064 nm脉冲激光光源对悬浮在琼脂模体中的HNPs的加热和散热监测。60秒后，粒子将经历高达40°C的加热，从直径1 mm的照射点开始，总散热面积高达132.73平方毫米。这项工作报告了基于我们的发现，这些颗粒在转化为癌症治疗方面的潜在和可能的缺陷。
Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon resonance of the gold coating, which usually occurs at the maximum UV absorption wavelength. However, lasers at such wavelength are often expensive and highly specialised. Here, we report the heating and monitoring of heat dissipation of HNPs suspended in agar phantoms using a relatively inexpensive Ng: YAG pulsed 1064 nm laser source. The particles experience heating of up to 40°C with a total area of heat dissipation up to 132.73 mm2 from the 1 mm diameter irradiation point after 60 seconds. This work reports the potential and possible drawbacks of these particles for translation into cancer therapy based on our findings.