Cell survival and metastasis regulation by Akt signaling in colorectal cancer.
Cell survival and metastasis regulation by Akt signaling in colorectal cancer.
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DOI：
10.1016/j.cellsig.2013.03.025
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发表时间：
2013-08
影响因子：
4.8
通讯作者：
Chowdhury S
中科院分区：
文献类型：
--
作者：
Agarwal E;Brattain MG;Chowdhury S
在不同类型的癌症中，癌细胞扩散到远处的器官部位是由于治疗失败而导致死亡的主要原因。Mehlen和Puisieux回顾了不适当的细胞存活信号在转移过程中各个步骤的重要性，并注意到异常细胞存活对转移部位成功定植的特别重要性。因此，了解控制这些转移细胞存活命运的机制可能会导致对转移潜能控制的新范式的理解，并可能为开发治疗转移的新策略提供基础。许多研究已经证明Akt在结直肠癌以及许多其他类型癌症的细胞存活和转移中发挥着广泛的作用。Akt作为一个关键的信号节点，在致癌受体与许多重要的促生存细胞功能之间架起桥梁，可能是人类癌症中最常见的激活信号通路。近年来，Akt2和Akt3已成为恶性肿瘤的重要贡献者，与已被充分表征的Akt1异构体一起，具有明显的非重叠功能。本综述旨在更好地了解促进癌症进展和转移的akt驱动细胞存活机制，以及旨在对抗癌症中akt驱动细胞存活反应的临床试验中的药理学抑制剂。
Dissemination of cancer cells to distant organ sites is the leading cause of death due to treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the importance of the development of inappropriate cell survival signalling for various steps in the metastatic process and have noted the particular importance of aberrant cell survival to successful colonization at the metastatic site. Therefore, the understanding of mechanisms that govern cell survival fate of these metastatic cells could lead to the understanding of a new paradigm for control of metastatic potential and could provide the basis for developing novel strategies for the treatment of metastases. Numerous studies have documented the widespread role of Akt in cell survival and metastasis in colorectal cancer, as well as many other types of cancer. Akt acts as a key signalling node that bridges the link between oncogenic receptors to many essential pro-survival cellular functions, and is perhaps the most commonly activated signalling pathway in human cancer. In recent years, Akt2 and Akt3 have emerged as significant contributors to malignancy alongside the well-characterized Akt1 isoform, with distinct non-overlapping functions. This review is aimed at gaining a better understanding of the Akt-driven cell survival mechanisms that contribute to cancer progression and metastasis and the pharmacological inhibitors in clinical trials designed to counter the Akt-driven cell survival responses in cancer.
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影响因子：
3.7
作者：
Chowdhury S;Howell GM;Rajput A;Teggart CA;Brattain LE;Weber HR;Chowdhury A;Brattain MG
通讯作者：
Brattain MG
影响因子：
4.8
作者：
Chowdhury, Sanjib;Howell, Gillian M.;Brattain, Michael G.
通讯作者：
Brattain, Michael G.
影响因子：
4.8
作者：
Ammanamanchi, S;Brattain, MG
通讯作者：
Brattain, MG
影响因子：
11.4
作者：
Chiarini, F.;Del Sole, M.;Martelli, A. M.
通讯作者：
Martelli, A. M.
影响因子：
4.8
作者：
Calera, MR;Martinez, C;Pilch, PF
通讯作者：
Pilch, PF