Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins.
Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins.
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女性性类固醇改变的皮肤循环反射控制与前列腺素无关。
DOI：
10.1152/ajpheart.1999.276.5.h1634
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Johnson,JM
中科院分区：
文献类型：
--
作者：
Charkoudian,N;Johnson,JM
我们验证了这样一种假设，即女性生殖激素升高时皮肤血管舒张剂对高温反应的转变是一种前列腺素依赖的体温调节重置，以适应更高的内部温度，类似于对细菌感染的发热反应。采用水灌注服控制体温，对静置女性进行低、高孕酮、高雌激素条件下的热应激实验，并在急性剂量布洛芬（800mg）后重复实验。6名妇女的激素是外源性的（口服避孕药）；三名女性有规律的月经周期，在卵泡早期和黄体中期进行了测试。激素水平高时静息口温（Tor）显著升高（P< 0.05）；布洛芬治疗对其无影响（P < 0.05）。高激素水平显著提高皮肤血管舒张的Torthreshold(+0.27±0.07°C，P< 0.02)；布洛芬治疗不影响移行（布洛芬组：+0.29±0.08°C，与对照组相比P < 0.05）。高激素水平的出汗托阈值升高（+0.22±0.05°C，P< 0.05）；布洛芬对这种变化没有影响（布洛芬组：+0.35±0.05，与对照组相比P < 0.05）。因此，女性生殖激素介导的皮肤血流量和出汗的体温调节控制的转变对布洛芬不敏感；因此，这种转变似乎与前列腺素无关。
We tested the hypothesis that the shift in the cutaneous vasodilator response to hyperthermia seen with elevated female reproductive hormones is a prostaglandin-dependent resetting of thermoregulation to higher internal temperatures, similar to that seen in the febrile response to bacterial infection. Using water-perfused suits to control body temperature, we conducted heat stress experiments in resting women under conditions of low and high progesterone and estrogen and repeated these experiments after an acute dose of ibuprofen (800 mg). In six women the hormones were exogenous (oral contraceptives); three women had regular menstrual cycles and were tested in the early follicular and midluteal phases. Resting oral temperature (Tor) was significantly elevated with high hormone status (P< 0.05); this was not affected by ibuprofen treatment (P> 0.2). The Torthreshold for cutaneous vasodilation was significantly increased by high hormone status (+0.27 ± 0.07°C,P< 0.02); the shift was not affected by ibuprofen treatment (with ibuprofen: +0.29 ± 0.08°C,P> 0.2 vs. control experiments). The Torthreshold for sweating was similarly increased by high hormone status (+0.22 ± 0.05°C,P< 0.05); this shift was not influenced by ibuprofen (with ibuprofen: +0.35 ± 0.05,P> 0.1 vs. control experiments). Thus the shift in thermoregulatory control of skin blood flow and sweating mediated by female reproductive steroids is not sensitive to ibuprofen; it therefore appears that this shift is independent of prostaglandins.