Altered Neuroanatomical Asymmetries of Subcortical Structures in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
Altered Neuroanatomical Asymmetries of Subcortical Structures in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
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主观认知衰退、遗忘性轻度认知障碍和阿尔茨海默病中皮质下结构的神经解剖学不对称性改变。
DOI：
10.3233/jad-201116
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发表时间：
2021-01-01
影响因子：
4
通讯作者：
Li, Shuyu
中科院分区：
文献类型：
--
作者：
Fu, Zhenrong;Zhao, Mingyan;Li, Shuyu
背景：主观认知能力下降（SCD）的个体，其定义为自我报告的记忆抱怨，但在客观神经心理学测试中表现正常，可能面临更高的风险恶化或更频繁的记忆丧失，直到转变为阿尔茨海默病（AD）或相关痴呆。两个半球的不对称性是人类大脑结构和功能的一个主要特征，大脑不对称性的改变也与AD有关。目的：本研究旨在确定 SCD 和遗忘性轻度认知障碍 (aMCI) 患者以及 AD 患者的皮质下结构不对称性与正常对照 (NC) 相比是否发生改变。方法：我们研究了 35 名 SCD、43 名 aMCI 和 41 名 AD 受试者与 42 名 NC 受试者相比的神经解剖学改变，重点关注基于结构磁共振图像 (sMRI) 的皮层下结构的不对称变化。采用一般线性模型来测试组间差异，并使用偏相关来模拟不对称测量和认知测试之间的相互作用。结果：SCD（侧脑室和小脑-WM）个体、aMCI 患者（侧脑室、苍白球、海马、杏仁核、伏隔核和腹侧 DC）和 AD 患者（侧脑室、小脑-皮质苍白球、丘脑、海马、杏仁核、伏隔核和腹侧 DC）表现出显着差异 与 NC 相比，改变了体积、表面积和形状的神经解剖学不对称性。在海马体和伏隔核中发现形状不对称与神经心理学检查之间存在显着关联。结论：在 SCD 个体、aMCI 患者以及 AD 患者中显着检测到皮质下结构的神经解剖学不对称性改变，这些特定的不对称性改变有可能用作神经影像学标志物和监测疾病进展。
Background: Individuals with subjective cognitive decline (SCD), defined by self-reported memory complaints but normal performance in objective neuropsychological tests, may be at higher risk of worsening or more frequent memory loss until conversion to Alzheimer’s disease (AD) or related dementia. Asymmetry in two hemispheres is a cardinal character of human brain’s structure and function, and altered brain asymmetry has also been connected with AD. Objective: This study aimed to determine whether the asymmetry of subcortical structures in individuals with SCD and amnestic mild cognitive impairment (aMCI) and AD patients are altered compared with normal controls (NC). Methods: We investigated neuroanatomical alterations in 35 SCD, 43 aMCI, and 41 AD subjects compared with 42 NC, focusing on asymmetrical changes in subcortical structures based on structural magnetic resonance images (sMRI). General linear model was conducted to test group differences, and partial correlation was used to model the interaction between asymmetry measurements and cognitive tests. Results: Individuals with SCD (lateral ventricle and cerebellum-WM), aMCI patients (lateral ventricle, pallidum, hippocampus, amygdala, accumbens, and ventral DC), and AD patients (lateral-ventricle, cerebellum-cortical pallidum, thalamus, hippocampus, amygdala, accumbens, and ventral DC) exhibited significant altered neuroanatomical asymmetries of volume, surface area, and shape compared with NC. Significant associations between shape asymmetry and neuropsychological examinations were found in the hippocampus and accumbens. Conclusion: Altered neuroanatomical asymmetries of subcortical structures were significantly detected in SCD individuals and aMCI patients as well AD patients, and these specific asymmetry alterations are potential to be used as neuroimaging markers and for monitoring disease progression.